Author | Soares, Milena Botelho Pereira | |
Author | Mota, Kátia N. Silva | |
Author | Lima, Ricardo Santana de | |
Author | Bellintani, Moema Cortizo | |
Author | Pontes-de-Carvalho, Lain Carlos | |
Author | Santos, Ricardo Ribeiro dos | |
Access date | 2012-09-19T19:16:06Z | |
Available date | 2012-09-19T19:16:06Z | |
Document date | 2001 | |
Citation | SOARES, M.B. et al. Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism. American Journal of Pathology, v. 159, n. 2, p. 703-709, Aug. 2001. | pt_BR |
ISSN | 0002-9440 | |
URI | https://www.arca.fiocruz.br/handle/icict/5531 | |
Language | eng | pt_BR |
Rights | open access | |
Title | Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism. | pt_BR |
Type | Article | pt_BR |
Abstract | Chronic chagasic cardiomyopathy (CChC) is characterized by an inflammatory reaction which may eventually lead to heart enlargement, arrythmia, and death. As described herein, interleukin-4-deficient mice mount increased specific T helper (Th) 1 immune responses when infected with Trypanosoma cruzi, as compared to wild-type mice. Interestingly, these mice had reduced parasitism and mortality and exacerbated inflammation in their hearts, demonstrating a clear dissociation between inflammation and parasite load. The modulation of these phenomena so as to maximize host and parasite survivals may depend on a fine balance between Th responses, in which a Th1 response will, on one hand, control parasitism and, on the other hand, enhance heart inflammation throughout the course of the infection | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
DeCS | Cardiomiopatia Chagásica/imunologia | pt_BR |
DeCS | Inflamação/imunologia | pt_BR |
DeCS | Interleucina-4/fisiologia | pt_BR |
DeCS | Parasitemia/imunologia | pt_BR |
DeCS | Linfócitos T Auxiliares-Indutores/imunologia | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Cardiomiopatia Chagásica/genética | pt_BR |
DeCS | Cardiomiopatia Chagásica/patologia | pt_BR |
DeCS | Imunidade Inata/genética | pt_BR |
DeCS | Imunidade Inata/imunologia | pt_BR |
DeCS | Inflamação/patologia | pt_BR |
DeCS | Interleucina-4/deficiência | pt_BR |
DeCS | Interleucina-4/genética | pt_BR |
DeCS | Ativação Linfocitária | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos BALB C | pt_BR |
DeCS | Camundongos Knockout | pt_BR |
DeCS | Camundongos Nus | pt_BR |
DeCS | Miocardite/genética | pt_BR |
DeCS | Miocardite/imunologia | pt_BR |
DeCS | Miocardite/patologia | pt_BR |
DeCS | Parasitemia/patologia | pt_BR |
DeCS | Fatores de Tempo | pt_BR |
DeCS | Trypanosoma cruzi | pt_BR |