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GENOMICS OF KLEBSIELLA PNEUMONIAE SPECIES COMPLEX REVEALS THE CIRCULATION OF HIGH-RISK MULTIDRUG-RESISTANT PANDEMIC CLONES IN HUMAN, ANIMAL, AND ENVIRONMENTAL SOURCES
Hipervirulência
Resistoma
Ambiente
Animal
Sideróforos
Yersiniabactina
Colibactina
T6SS
Hypervirulence
Resistome
Environment
Animal
Siderophores
Yersiniabactin
Colibactin
T6SS
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ, Brasil.
Abstract
The Klebsiella species present a remarkable genetic and ecological diversity, being ubiquitous
in nature. In particular, the Klebsiella pneumoniae species complex (KpSC) has emerged as a major
public health threat in the world, being an interesting model to assess the risk posed by strains recovered
from animals and the environment to humans. We therefore performed a genomic surveillance
analysis of the KpSC using every public genome in Brazil, aiming to show their local and global
relationships, and the connectivity of antibiotic resistance and virulence considering human, animal,
and environmental sources. The 390 genomes from distinct sources encompassed the K. pneumoniae,
Klebsiella quasipneumoniae subsp. quasipneumoniae, Klebsiella quasipneumoniae subsp. similipneumoniae,
Klebsiella variicola subsp. variicola, Klebsiella variicola subsp. tropica, and Klebsiella grimontii species and
subspecies. K. pneumoniae harbored dozens of antibiotic resistance genes, while most of the genomes
belong to the high-risk pandemic CC258 occurring in humans, animals, and the environment. In
K. pneumoniae ST11, a high prevalence of the virulence determinants yersiniabactin, colibactin, and
T6SS was revealed in association with multi-drug resistance (MDR), including carbapenem resistance.
A diversity of resistance genes is carried by plasmids, some shared between strains from different
STs, regions, and sources. Therefore, here were revealed some factors driving the success of KpSC as
a pathogen.
Keywords in Portuguese
EpidemiologiaHipervirulência
Resistoma
Ambiente
Animal
Sideróforos
Yersiniabactina
Colibactina
T6SS
Keywords
EpidemiologyHypervirulence
Resistome
Environment
Animal
Siderophores
Yersiniabactin
Colibactin
T6SS
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