Author | Marra, Lays P. | |
Author | Sartori, Ana L. | |
Author | Martinez-Silveira, Martha Silvia | |
Author | Toscana, Cristiana M. | |
Author | Andrade, Ana L. | |
Access date | 2023-02-01T13:58:33Z | |
Available date | 2023-02-01T13:58:33Z | |
Document date | 2022 | |
Citation | MARRA, Lays P. et al. Effectiveness of pneumococcal vaccines on otitis media in children: a systematic review. Value in Health, v. 25, n. 6, p. 1-45, 2022. | en_US |
ISSN | 1524-4733 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/56805 | |
Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). | en_US |
Language | eng | en_US |
Publisher | Elsevier | en_US |
Rights | open access | en_US |
Subject in Portuguese | Pesquisa de eficácia comparativa | en_US |
Subject in Portuguese | Vacinas conjugadas | en_US |
Subject in Portuguese | Inflamação na orelha | en_US |
Subject in Portuguese | Vacinas pneumocócicas | en_US |
Subject in Portuguese | Vacina polissacarídica | en_US |
Subject in Portuguese | Revisão sistemática | en_US |
Title | Effectiveness of pneumococcal vaccines on otitis media in children: a systematic review | en_US |
Type | Article | en_US |
DOI | 10.1016/j.jval.2021.12.012 | |
Abstract | Objectives: We aimed to determine the effectiveness of pneumococcal vaccines on otitis media (OM) and acute otitis media (AOM) in children. Methods: We conducted a systematic search in databases PubMed (MEDLINE), Embase, Lilacs, and Web of Science. We included observational studies that evaluated any pneumococcal vaccine – including 7, 10, and 13-valent pneumococcal conjugate vaccines (PCV7, PCV10, and PCV13) and 23-valent polysaccharide vaccines (PPSV23) as the intervention, in children aged less than five years. Results: Out of the 2112 screened studies, 48 observational studies complied with the eligibility criteria and therefore were included in this review. Of the included studies, 30 (63%) were before-after, eleven (23%) cohort, six (13%) time series, and one (2%) case-control study designs. Vaccine effectiveness (VE) in preventing OM or AOM varied by vaccine type. In children under 24 months VE ranged from 8% and 42.7% (PCV7), 5.6% to 84% (PCV10) and 2.2% to 68% (PCV13). In children aged less than 60 months, VE ranged between 13.2% and 39% for PCV7, 11% to 39% for PCV10 (only children under 48 months), and 39% to 41% (PCV13). Conclusions: Our results demonstrate significant effect of pneumococcal vaccination in decreasing OM or AOM in children under five years old in several countries supporting the public health value of introducing PCVs in national immunization programs. | en_US |
Affilliation | Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Departamento de Saúde Coletiva. Goiânia, GO, Brasil. | en_US |
Affilliation | Universidade Federal de Mato Grosso. Instituto de Ciências da Saúde. Sinop, RS, Brasil. | en_US |
Affilliation | Fundação Oswald Cruz. Instituto Gonçalo Moniz. Biblioteca Eurydice Pires de Sant'Anna. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Departamento de Saúde Coletiva. Goiânia, GO, Brasil. | en_US |
Affilliation | Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Departamento de Saúde Coletiva. Goiânia, GO, Brasil. | en_US |
Subject | Comparative effectiveness research | en_US |
Subject | Conjugate vaccines | en_US |
Subject | Otitis media | en_US |
Subject | Pneumococcal vaccines | en_US |
Subject | Polysaccharide vaccine | en_US |
Subject | Systematic review | en_US |
DeCS | Pesquisa comparativa da efetividade | en_US |
DeCS | Vacinas conjugadas | en_US |
DeCS | Vacinas pneumocócicas | en_US |
DeCS | Revisão sistemática | en_US |