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https://www.arca.fiocruz.br/handle/icict/60753
EVOLUTIONARY AND FUNCTIONAL HISTORY OF THE ESCHERICHIA COLI K1 CAPSULE
Infecções bacterianas
Humanos
Polissacarídeo de cápsula
Patogênese bacteriana
Cápsula K1
Bacterial infections
Humans
Capsule polysaccharide
Bacterial pathogenesis
K1 capsule
Autor(es)
Alonso, Sergio Arredondo
Hunter, George Blundell
Fu, Zuyi
Gladstone, Rebecca A.
Salom, Alfred Fillol
Loraine, Jessica
Green, Elaine Cloutman
Johnsen, Pål J.
Samuelsen, Ørjan
Pöntinen, Anna K.
Cléon, François
Bueno, Susana Chavez
Cruz, Miguel A. de la
Ares, Miguel A.
Vongsouvath, Manivanh
Chmielarczyk, Agnieszka
Horner, Carolyne
Klein, Nigel
McNally, Alan
Reis, Joice N.
Penadés, José R.
Thomson, Nicholas R.
Corander, Jukka
Taylor, Peter W.
McCarthy, Alex J.
Hunter, George Blundell
Fu, Zuyi
Gladstone, Rebecca A.
Salom, Alfred Fillol
Loraine, Jessica
Green, Elaine Cloutman
Johnsen, Pål J.
Samuelsen, Ørjan
Pöntinen, Anna K.
Cléon, François
Bueno, Susana Chavez
Cruz, Miguel A. de la
Ares, Miguel A.
Vongsouvath, Manivanh
Chmielarczyk, Agnieszka
Horner, Carolyne
Klein, Nigel
McNally, Alan
Reis, Joice N.
Penadés, José R.
Thomson, Nicholas R.
Corander, Jukka
Taylor, Peter W.
McCarthy, Alex J.
Afiliação
Department of Biostatistics. University of Oslo. Oslo, Norway / Parasites and Microbes. Wellcome Sanger Institute. Cambridge, UK.
School of Pharmacy. University College London. London, UK.
Department of Infectious Disease. Centre for Bacterial Resistance Biology. Imperial College London. London, UK.
Department of Biostatistics. University of Oslo. Oslo, Norway / Parasites and Microbes. Wellcome Sanger Institute. Cambridge, UK.
Department of Infectious Disease. Centre for Bacterial Resistance Biology. Imperial College London. London, UK.
School of Pharmacy. University College London. London, UK.
Great Ormond Street Institute of Child Health. University College London. London, UK.
Department of Pharmacy. Faculty of Health Sciences. UiT the Arctic University of Norway. Tromsø, Norway.
Department of Pharmacy. Faculty of Health Sciences. UiT the Arctic University of Norway. Tromsø, Norway / Norwegian National Advisory Unit on Detection of Antimicrobial Resistance. Department of Microbiology and Infection Control. University Hospital of North Norway. Tromsø, Norway.
Department of Biostatistics. University of Oslo. Oslo, Norway / Norwegian National Advisory Unit on Detection of Antimicrobial Resistance. Department of Microbiology and Infection Control. University Hospital of North Norway. Tromsø, Norway.
Department of Pharmacy. Faculty of Health Sciences. UiT the Arctic University of Norway. Tromsø, Norway.
University of Missouri Kansas City. Kansas City, USA / Division of Infectious Diseases. Children’sMercy Hospital Kansas City. UMKC School of Medicine, Kansas City, USA.
Unidad de InvestigaciónMédica en Enfermedades Infecciosas y Parasitarias. Hospital de Pediatría, Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social. Mexico City, Mexico / Facultad de Medicina. Benemérita Universidad Autónoma de Puebla. Puebla, Mexico.
Unidad de InvestigaciónMédica en Enfermedades Infecciosas y Parasitarias. Hospital de Pediatría, Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social. Mexico City, Mexico
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU). Microbiology Laboratory,MahosotHospital. Vientiane, Lao PDR.
Faculty of Medicine. Chair of Microbiology. Jagiellonian University Medical College. Kraków, Poland.
British Society for Antimicrobial Chemotherapy. Birmingham, UK.
Great Ormond Street Institute of Child Health. University College London. London, UK.
Institute of Microbiology and Infection. College of Medical and Dental Sciences. University of Birmingham. Birmingham, UK.
Fundação Oswaldo Cruz. Instituto de Investigação Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.
Department of Infectious Disease. Centre for Bacterial Resistance Biology. Imperial College London. London, UK.
Parasites and Microbes. Wellcome Sanger Institute. Cambridge, UK / London School of Hygiene and Tropical Medicine. London, UK.
Department of Biostatistics. University of Oslo. Oslo, Norway / Parasites and Microbes. Wellcome Sanger Institute. Cambridge, UK / Helsinki Institute of Information Technology. Department of Mathematics and Statistics. University of Helsinki. Helsinki, Finland.
School of Pharmacy. University College London. London, UK.
Department of Infectious Disease. Centre for Bacterial Resistance Biology. Imperial College London. London, UK.
School of Pharmacy. University College London. London, UK.
Department of Infectious Disease. Centre for Bacterial Resistance Biology. Imperial College London. London, UK.
Department of Biostatistics. University of Oslo. Oslo, Norway / Parasites and Microbes. Wellcome Sanger Institute. Cambridge, UK.
Department of Infectious Disease. Centre for Bacterial Resistance Biology. Imperial College London. London, UK.
School of Pharmacy. University College London. London, UK.
Great Ormond Street Institute of Child Health. University College London. London, UK.
Department of Pharmacy. Faculty of Health Sciences. UiT the Arctic University of Norway. Tromsø, Norway.
Department of Pharmacy. Faculty of Health Sciences. UiT the Arctic University of Norway. Tromsø, Norway / Norwegian National Advisory Unit on Detection of Antimicrobial Resistance. Department of Microbiology and Infection Control. University Hospital of North Norway. Tromsø, Norway.
Department of Biostatistics. University of Oslo. Oslo, Norway / Norwegian National Advisory Unit on Detection of Antimicrobial Resistance. Department of Microbiology and Infection Control. University Hospital of North Norway. Tromsø, Norway.
Department of Pharmacy. Faculty of Health Sciences. UiT the Arctic University of Norway. Tromsø, Norway.
University of Missouri Kansas City. Kansas City, USA / Division of Infectious Diseases. Children’sMercy Hospital Kansas City. UMKC School of Medicine, Kansas City, USA.
Unidad de InvestigaciónMédica en Enfermedades Infecciosas y Parasitarias. Hospital de Pediatría, Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social. Mexico City, Mexico / Facultad de Medicina. Benemérita Universidad Autónoma de Puebla. Puebla, Mexico.
Unidad de InvestigaciónMédica en Enfermedades Infecciosas y Parasitarias. Hospital de Pediatría, Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social. Mexico City, Mexico
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU). Microbiology Laboratory,MahosotHospital. Vientiane, Lao PDR.
Faculty of Medicine. Chair of Microbiology. Jagiellonian University Medical College. Kraków, Poland.
British Society for Antimicrobial Chemotherapy. Birmingham, UK.
Great Ormond Street Institute of Child Health. University College London. London, UK.
Institute of Microbiology and Infection. College of Medical and Dental Sciences. University of Birmingham. Birmingham, UK.
Fundação Oswaldo Cruz. Instituto de Investigação Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.
Department of Infectious Disease. Centre for Bacterial Resistance Biology. Imperial College London. London, UK.
Parasites and Microbes. Wellcome Sanger Institute. Cambridge, UK / London School of Hygiene and Tropical Medicine. London, UK.
Department of Biostatistics. University of Oslo. Oslo, Norway / Parasites and Microbes. Wellcome Sanger Institute. Cambridge, UK / Helsinki Institute of Information Technology. Department of Mathematics and Statistics. University of Helsinki. Helsinki, Finland.
School of Pharmacy. University College London. London, UK.
Department of Infectious Disease. Centre for Bacterial Resistance Biology. Imperial College London. London, UK.
Resumo em Inglês
Escherichia coli is a leading cause of invasive bacterial infections in humans. Capsule polysaccharide has an important role in bacterial pathogenesis, and the K1 capsule has been firmly established as one of the most potent capsule types in E. coli through its association with severe infections. However, little is known about its distribution, evolution and functions across the E. coli phylogeny, which is fundamental to elucidating its role in the expansion of successful lineages. Using systematic surveys of invasive E. coli isolates, we show that the K1-cps locus is present in a quarter of bloodstream infection isolates and has emerged in at least four different extraintestinal pathogenic E. coli (ExPEC) phylogroups independently in the last 500 years. Phenotypic assessment demonstrates that K1 capsule synthesis enhances E. coli survival in human serum independent of genetic background, and that therapeutic targeting of the K1 capsule re-sensitizes E. coli from distinct genetic backgrounds to human serum. Our study highlights that assessing the evolutionary and functional properties of bacterial virulence factors at population levels is important to better monitor and predict the emergence of virulent clones, and to also inform therapies and preventive medicine to effectively control bacterial infections whilst significantly lowering antibiotic usage.
Palavras-chave
Escherichia coliInfecções bacterianas
Humanos
Polissacarídeo de cápsula
Patogênese bacteriana
Cápsula K1
Palavras-chave em inglês
Escherichia coliBacterial infections
Humans
Capsule polysaccharide
Bacterial pathogenesis
K1 capsule
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