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3100-12-31
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EFFECTS OF INTERACTIONS BETWEEN APOE POLYMORPHISMS, ALCOHOL CONSUMPTION AND OBESITY ON AGE-RELATED TRENDS OF BLOOD PRESSURE LEVELS IN POSTMENOPAUSAL WOMEN: THE BAMBUÌ COHORT STUDY OF AGING (1997–2008)
Affilliation
Institute of Biomedical Technologies/CNR. National Research Council. Milan, Italy
Federal University of Rio Grande do Sul. Porto Alegre, RS, Brasil /University of Vale dos Sinos. São Leopoldo, RS, Brasil/Moinho de Vento Hospital. Porto Alegre, RS, Brazil
Oswaldo Cruz Foundation. Rene Rachou Research Institute. Belo Horizonte, MG, Brasil/Federal University of Minas Gerais. Medical School. Belo Horizonte, MG, Brasil
Federal University of Rio Grande do Sul. Porto Alegre, RS, Brasil /University of Vale dos Sinos. São Leopoldo, RS, Brasil/Moinho de Vento Hospital. Porto Alegre, RS, Brazil
Oswaldo Cruz Foundation. Rene Rachou Research Institute. Belo Horizonte, MG, Brasil/Federal University of Minas Gerais. Medical School. Belo Horizonte, MG, Brasil
Abstract
Objectives: To evaluate the effects of interactions between ApoE genotypes, alcohol consumption and obesity on the age-related trends of blood pressure (BP) levels in postmenopausal women. Study design: A population-based prospective cohort study of all residents in Bambuì, south-eastern Brazil, aged 60 years or older. Repeated BP measurements were obtained in four waves from 851 women who underwent ApoE genotyping at baseline (88.3% of those enrolled), and multi-level random-effects pattern-mixture models were used to evaluate the age-related BP trajectories, while accounting for non-ignorable dropouts/deaths and handling heterogeneities as random parameter variations. The few measurements (2.1%) made during hormone replacement therapy were excluded from the analysis. Results: Alcohol consumption was associated with high levels of systolic and diastolic BP in an age × genotype-dependent manner only in the non-obese women (BMI < 27 kg/m2). Among those with the 3/3 genotype, the differences in systolic and diastolic levels between drinkers and non-drinkers estimated at the age of 60 years were respectively 13.7 mmHg (p = 0.022) and 10.7 mmHg (p = 0.002), and disappearedinthe older age groups,in whichdrinking was associated withsystolic/diastolichypertension if the non-obese women were 4 carriers. Conclusion: In non-obese postmenopausal women, alcohol consumption is associated with systolic and diastolic hypertension early in those with the 3/3 ApoE genotype, and late in 4 carriers.We hypothesize the mediation of androgen hormones and the influence of ApoE genotypes on age at natural menopause. A better understanding of these mechanisms may guide better preventive choices.
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