Author | Duarte, Giselle da Silva | |
Author | Jones, Alexandra D. | |
Author | Cavalcanti, Luciano Pamplona de Goes | |
Author | Rêgo, Moacyr Jesus Barreto de Melo | |
Author | Ribeiro, Guilherme S. | |
Author | Boyton, Rosemary J. | |
Author | Pereira, Dhelio Batista | |
Author | Croda, Júlio Henrique Rosa | |
Author | Costa, Fabio Trindade Maranhão | |
Author | Duarte, Angela Pinto | |
Author | Consolaro, Marcia Edilaine Lopes | |
Author | Stabeli, Rodrigo Guerino | |
Author | Negrão, Fábio Juliano | |
Author | Modena, Jose Luiz Proenca | |
Author | Salcedo, Juan Miguel Villalobos | |
Author | Pinheiro, Geraldo da Rocha Castelar | |
Author | Albuquerque, Amanda Pinheiro de Barros | |
Author | Barreto, Francisca Kalline de Almeida | |
Author | Moreira, José | |
Author | Ferrari, Idalina Cristina | |
Author | Évora, Patricia Martinez | |
Author | Silva, Vânia Ramos Sela da | |
Author | Lacerda, Marcus Vinicius Guimarães | |
Author | Altmann, Daniel M. | |
Author | Siqueira, André M. | |
Access date | 2023-11-07T15:27:09Z | |
Available date | 2023-11-07T15:27:09Z | |
Document date | 2023 | |
Citation | DUARTE, Giselle da Silva et al. Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network). BMC Infectious Diseases, v. 23, n. 499, p. 1-12, 2023. | en_US |
ISSN | 1471-2334 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/61064 | |
Description | For the investigators of the REPLICK Network: Thyago Henrique Pereira dos Santos, Fernanda Montenegro de Carvalho Araujo; Luis Arthur Brazil Gadelha Farias, Lara Moreira Teles de Vasconcelos; Brena Ferreira dos Santos; Shamyr Sulyvan de Castro; Marina Carvalho Arruda Barreto; Ileana Pitombeira Gomes; Jobson Lopes de Oliveira; Thayanne Vitoria Nunes Pinheiro; Samara Bezerra Guedes das Neves; Carla Cristiana Judice; Gabriela Fabiano de Souza; Matheus Cavalheiro Martini; Deusilene Souza Vieira Dall’Acqua; Marcela Macedo de Oliveira; Eduardo Garbin; Alexia Martines; Maira Galdino da Rocha Pitta; Luiz Demarchi; Caroline Santos Soares. | |
Sponsorship | Departamento de Ciência e Tecnologia da Ministério da Saúde do Brasil. Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP). | en_US |
Language | eng | en_US |
Publisher | BMC | en_US |
Rights | open access | en_US |
Subject in Portuguese | Chikungunya | en_US |
Subject in Portuguese | Coorte | en_US |
Subject in Portuguese | Brasil | en_US |
Subject in Portuguese | Manifestações reumáticas | en_US |
Title | Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network) | en_US |
Type | Article | en_US |
DOI | 10.1186/s12879-023-08292-y | |
Abstract | Background: Chikungunya is associated with high morbidity and the natural history of symptomatic infection has been divided into three phases (acute, post-acute, and chronic) according to the duration of musculoskeletal symptoms. Although this classification has been designed to help guide therapeutic decisions, it does not encompass the complexity of the clinical expression of the disease and does not assist in the evaluation of the prognosis of severity nor chronic disease. Thus, the current challenge is to identify and diagnose musculoskeletal disorders and to provide the optimal treatment in order to prevent perpetuation or progression to a potentially destructive disease course. Methods: The study is the first product of the Clinical and Applied Research Network in Chikungunya (REPLICK). This is a prospective, outpatient department-based, multicenter cohort study in Brazil. Four work packages were defined: i. Clinical research; ii) Translational Science – comprising immunology and virology streams; iii) Epidemiology and Economics; iv) Therapeutic Response and clinical trials design. Scheduled appointments on days 21 (D21) ± 7 after enrollment, D90 ± 15, D120 ± 30, D180 ± 30; D360 ± 30; D720 ± 60, and D1080 ± 60 days. On these visits a panel of blood tests are collected in addition to the clinical report forms to obtain data on socio-demographic, medical history, physical examination and questionnaires devoted to the evaluation of musculoskeletal manifestations and overall health are performed. Participants are asked to consent for their specimens to be maintained in a biobank. Aliquots of blood, serum, saliva, PAXgene, and when clinically indicated to be examined, synovial fluid, are stored at -80° C. The study protocol was submitted and approved to the National IRB and local IRB at each study site. Discussion Standardized and harmonized patient cohorts are needed to provide better estimates of chronic arthralgia development, the clinical spectra of acute and chronic disease and investigation of associated risk factors. This study is the largest evaluation of the long-term sequelae of individuals infected with CHIKV in the Brazilian population focusing on musculoskeletal manifestations, mental health, quality of life, and chronic pain. This information will both define disease burden and costs associated with CHIKV infection, and better inform therapeutic guidelines. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | University of California. Berkeley, USA. | en_US |
Affilliation | Universidade Federal do Ceara. Fortaleza, CE, Brasil. | en_US |
Affilliation | Universidade Federal de Pernambuco. Departamento de Bioquímica. Recife, PE, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Imperial College of London, London, UK. | en_US |
Affilliation | Centro de Pesquisa em Medicina Tropical de Rondônia. Porto Velho, RO, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil. | en_US |
Affilliation | Universidade Estadual de Campinas. Campinas, Brasil. | en_US |
Affilliation | Hospital das Clínicas, Universidade Federal de Pernambuco, Recife, Brasil. | en_US |
Affilliation | Universidade Estadual de Maringá. Departamento de Análises Clínicas e Biomedicina. Maringá, PR, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Fiocruz São Paulo. Plataforma de Medicina Translacional. São Paulo, SP, Brasil. | en_US |
Affilliation | Universidade Federal da Grande Dourados. Dourados, MS, Brasil. | en_US |
Affilliation | Universidade Estadual de Campinas. Campinas, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Fiocruz São Paulo. São Paulo, SP, Brasil. | en_US |
Affilliation | Universidade Estadual do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal de Pernambuco. Departamento de Bioquímica. Recife, PE, Brasil. | en_US |
Affilliation | Universidade Federal do Ceara. Fortaleza, CE, Brasil. | en_US |
Affilliation | Universidade Federal da Grande Dourados. Dourados, MS, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Fiocruz São Paulo. Plataforma de Medicina Translacional. São Paulo, SP, Brasil. | en_US |
Affilliation | Universidade Estadual de Maringá. Departamento de Análises Clínicas e Biomedicina. Maringá, PR, Brasil. | en_US |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil. | en_US |
Affilliation | Imperial College of London, London, UK. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil. | en_US |
Subject | Chikungunya | en_US |
Subject | Cohort | en_US |
Subject | Brazil | en_US |
Subject | Rheumatic manifestations | en_US |
DeCS | Chikungunya | en_US |
DeCS | Coorte | en_US |
DeCS | Brasil | en_US |
DeCS | Doenças reumáticas | en_US |