Author | Rebolledo, Anayive Pérez | |
Author | Beraldo, Heloisa | |
Author | Vieites, Marisol | |
Author | Gambino, Dinorah | |
Author | Piro, Oscar Enrique | |
Author | Castellano, Eduardo Ernesto | |
Author | Zani, Carlos Leomar | |
Author | Fagundes, Elaine Maria de Souza | |
Author | Teixeira, Letícia Regina de Souza | |
Author | Batista, Alzir Azevedo | |
Access date | 2013-08-08T19:00:31Z | |
Available date | 2013-08-08T19:00:31Z | |
Document date | 2005 | |
Citation | PEREZ-REBOLLEDO, Anayive et al. Palladium(II) complexes of 2-benzoylpyridine-derived thiosemicarbazones: spectral characterization, structural studies and cytotoxic activity. J Inorg Biochem. 2005 Mar;99(3):698-706. | pt_BR |
ISSN | 0162-0134 | |
URI | https://www.arca.fiocruz.br/handle/icict/6774 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Title | Palladium(II) complexes of 2-benzoylpyridine-derived thiosemicarbazones: spectral characterization, structural studies and cytotoxic activity. | pt_BR |
Type | Article | pt_BR |
Abstract | Palladium(II) complexes of 2-benzoylpyridine thiosemicarbazone (H2Bz4DH) and its N(4)-methyl (H2Bz4M) and N(4)-phenyl (H2Bz4Ph) derivatives were obtained and fully characterized. [Pd(2Bz4DH)Cl] (1) crystallizes in the monoclinic space groupP21 /c witha= 11.671(1),b= 10.405(1),c= 13.124(1),b= 115.60(1) and Z= 4; [Pd(2Bz4M)Cl] (2) in the monoclinic space group P21/cwitha= 9.695(1),b= 15.044(1),c= 10.718(1) A˚, b= 105.38(1)andZ= 4 and [Pd(2Bz4Ph)Cl] (3) in the triclinic space group P1 witha= 9.389(1),b= 13.629(1),c= 15.218(1) A˚ , a= 70.25(1),b= 73.46(1),c= 83.57(1)and two independent molecules per asymmetric unit (Z= 4). All complexes show a quite similar planar fourfold environment around palladium(II). A negatively charged organic molecule acts as a tridentate ligand and binds to the metal through the pyridine nitrogen, the imine nitrogen and the sulfur atom. A chloride ion occupies the fourth coordination site. The planar complexes stack nearly parallel to one another in the lattice conforming a layered crystal structure. The cytotoxic activity of the thiosemicarbazones and their metal complexes was tested against the MCF-7, TK-10 and UACC-62 human tumor cell lines. The ligands exhibit lower values of GI50and LC50 than the complexes, H2Bz4Ph being the most active with GI50< 0.003lM; LC50= 13.4lM; GI50= 9.3lM, LC50= 12.9lM; GI50< 0.003, LC50= 13.8lM in the MCF-7, TK-10 and UACC-62 cell lines, respectively. Among the complexes, [Pd(2Bz4Ph)Cl] (3) exhibited the lowest values of GI50in the three studied cell lines. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Quımica. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Departamento de Quımica. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidad de la Republica. Facultad de Quımica. Catedra de Quımica Inorganica. Montevideo, Uruguay. | pt_BR |
Affilliation | Universidad de la Republica. Facultad de Quımica. Catedra de Quımica Inorganica. Montevideo, Uruguay. | pt_BR |
Affilliation | Universidad Nacional de La Plata and Instituto. Facultad de Ciencias Exactas. Departamento de Fısica. La Plata, Argentina. | pt_BR |
Affilliation | Universidade de Sao Paulo. Instituto de Fısica de Sao Carlos. Sao Carlos, SP, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Sao Carlos. Departamento de Quımica. Sao Carlos, SP, Brazil. | pt_BR |
Affilliation | Universidade Federal de Sao Carlos. Departamento de Quımica. Sao Carlos, SP, Brazil. | pt_BR |
Subject | Thiosemicarbazones | pt_BR |
Subject | Palladium complexes | pt_BR |
Subject | Structural studies | pt_BR |
Subject | Cytotoxic activity | pt_BR |