Author | Moura, Carlos Geraldo Guerreiro de | |
Author | Lima, Isabella | |
Author | Barbosa, Lúcio Macedo | |
Author | Athanazio, Daniel Abensur | |
Author | Reis, Eliana Almeida Gomes | |
Author | Reis, Mitermayer Galvão dos | |
Author | Burlingame, Rufus W. | |
Author | Santiago, Mittermayer Barreto | |
Access date | 2014-04-14T17:10:50Z | |
Available date | 2014-04-14T17:10:50Z | |
Document date | 2009 | |
Citation | MOURA, C. G. et al. Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus. Journal of Clinical Laboratory Analisis, v. 23, p. 19-23, 2009. | pt_BR |
ISSN | 1098-2825 | |
URI | https://www.arca.fiocruz.br/handle/icict/7517 | |
Language | eng | pt_BR |
Publisher | Wiley Periodicals | pt_BR |
Rights | open access | pt_BR |
Title | Anti-C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus | pt_BR |
Type | Article | pt_BR |
DOI | 10.1002/jcla.20280 | pt_BR |
Abstract | BACKGROUND: Anti-C1q antibodies have been described in systemic lupus erythematosus (SLE) as well as in other connective tissue diseases. They have been considered as a marker for disease activity and presence of nephritis. OBJECTIVE: The aim of this study was to determine the prevalence of anti-C1q antibodies in Brazilian lupus patients as well as analyze their association with different clinical and serologic parameters. METHODS: Sera from 81 SLE patients, based on the American College of Rheumatology (ACR) criteria, were collected from a lupus referral outpatient clinic in Salvador, Brazil. Antibodies to C1q were detected by an enzyme-linked immunoassay (ELISA) kit and antibodies to other cellular antigens identified by indirect immunofluorescence on HEp-2 cell substrate (ANA), or Crithidia luciliae (dsDNA), and to nucleosome by ELISA. A cutoff of 20 U was established for anti-C1q and anti nucleosome assays. RESULTS: Anti-C1q antibodies were detected in 39.5% (32/81) of SLE sera. The presence of anti-C1q antibodies was associated with proteinuria (P=0.028) but not with other laboratory or clinical features, such as anti nucleosome or anti-dsDNA antibodies, hematuria, urinary casts or renal failure, leukopenia, pericarditis, pleuritis, malar rash, seizures, and psychosis. There was a positive correlation between the titers of anti-C1q antibodies and the systemic lupuis erythematosus disease activity index (SLEDAI) score (r=0.370; P=0.001). CONCLUSION: This study in Brazilian SLE patients confirms previous findings of the association of anti-C1q antibodies with nephritis and disease activity. | pt_BR |
Affilliation | Hospital Santo Antônio. Escola Bahiana de Medicina e Saude Publica. Salvador, BA, Brasil. | pt_BR |
Affilliation | Hospital do Santa Izabel. Serviço de Reumatologia. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
Affilliation | INOVA Diagnostics Inc. San Diego, Califórnia, USA. | pt_BR |
Affilliation | Escola Bahiana de Medicina e Saúde Publica. Serviço de Reumatologia do Hospital do Santa Izabel. Salvador, BA, Brasil. | pt_BR |
Subject | Autoantibodies | pt_BR |
Subject | Anti-C1q antibodies | pt_BR |
Subject | Systemic lupus erythematosus | pt_BR |
Subject | Nephritis | pt_BR |
DeCS | Autoanticorpos/análise | pt_BR |
DeCS | Complemento C1q/imunologia | pt_BR |
DeCS | Lúpus Eritematoso Sistêmico/imunologia | pt_BR |
DeCS | Nefrite/imunologia | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Brasil | pt_BR |
DeCS | Estudos Transversais | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Técnica Indireta de Fluorescência para Anticorpo | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Estatísticas não Paramétricas | pt_BR |