Author | Lima, José Geraldo Bomfim | |
Author | Vinhas, Christiana de Freitas | |
Author | Gomes, Ivana Nunes | |
Author | Azevedo, Carine Machado | |
Author | Santos, Ricardo Ribeiro dos | |
Author | Santos, Marcos André Vannier dos | |
Author | Veras, Patrícia Sampaio Tavares | |
Access date | 2014-05-30T16:56:31Z | |
Available date | 2014-05-30T16:56:31Z | |
Document date | 2011 | |
Citation | LIMA, J. G. B. et al. Phagocytosis is inhibited by autophagic induction in murine macrophages. Biochemical and Biophysical Research Communications, v. 405, n. 4, p. 604-609, 2011. | pt_BR |
ISSN | 1090-2104 | |
URI | https://www.arca.fiocruz.br/handle/icict/7731 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Phagocytosis is inhibited by autophagic induction in murine macrophages. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.bbrc.2011.01.076 | |
Abstract | Recent studies have demonstrated that communication takes place between the autophagic and phagocytic
pathways, indicating that the convergence of these two pathways plays an important role in the
innate immune response against intracellular microbes. The present study investigated the effect of autophagic
induction on the phagocytic capacity of murine macrophages. Autophagy induced by physiological
and pharmacological means was shown to reduce the phagocytic capacity of murine macrophages,
regardless of cell origin or the nature of the phagocytosed particles themselves. This autophagic inhibitory
effect on phagocytosis was shown to be an early and reversible event that results in no loss of cell
viability. Furthermore, the data presented herein demonstrate that the induction of autophagy does not
affect a macrophage’s capacity to recognize and bind to particles, indicating that autophagy does not inhibit
the particle recognition process, even though particle internalization is suppressed. The findings
herein support the notion that phagocytosis and autophagy may be interdependent and complementary
processes | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biologia Parasitária. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biointervenção. Salvador, BA, Brasil | pt_BR |
Subject | Autophagy | pt_BR |
Subject | Phagocytosis | pt_BR |
Subject | Large particles | pt_BR |
Subject | Starvation | pt_BR |
Subject | Rapamycin | pt_BR |
Subject | Macrophage | pt_BR |
DeCS | Autofagia | pt_BR |
DeCS | Macrófagos/fisiologia | pt_BR |
DeCS | Fagocitose | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Linhagem Celular | pt_BR |
DeCS | Leishmania | pt_BR |
DeCS | Macrófagos/microbiologia | pt_BR |
DeCS | Macrófagos/parasitologia | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos BALB C | pt_BR |
DeCS | Saccharomyces cerevisiae | pt_BR |