Author | Quintans, Jullyana de Souza Siqueira | |
Author | Barreto, Rosana Siqueira de Souza | |
Author | Lucca Júnior, Waldecy de | |
Author | Villarreal, Cristiane Flora | |
Author | Kaneto, Carla Martins | |
Author | Soares, Milena Botelho Pereira | |
Author | Branco, Alexsandro | |
Author | Almeida, Jackson Roberto Guedes da Silva | |
Author | Taranto, Alex Gutterres | |
Author | Antoniolli, Angelo Roberto | |
Author | Freitas, Rivelilson Mendes de | |
Author | Quintans Junior, Lucindo José | |
Access date | 2014-09-26T18:58:13Z | |
Available date | 2014-09-26T18:58:13Z | |
Document date | 2014 | |
Citation | QUINTANS, J. S. S. et al. Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice. Molecules, v. 19, n. 6, p. 8303-8316, 2014. | pt_BR |
ISSN | 1420-3049 | |
URI | https://www.arca.fiocruz.br/handle/icict/8461 | |
Language | eng | pt_BR |
Publisher | MDPI | pt_BR |
Rights | open access | pt_BR |
Title | Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice. | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/molecules19068303 | |
Abstract | Hecogenin is a steroidal sapogenin largely drawn from the plants of the genus Agave, commonly known as 'sisal', and is one of the important precursors used by the pharmaceutical industry for the synthesis of steroid hormones. Hecogenin acetate (HA) is a steroidal sapogenin-acetylated that produces antinociceptive activity. Thus, we evaluate the antihyperalgesic profile of HA in mice in inflammatory models, as well as its possible involvement with c-fos expression on spinal cord area and cytokines to produces analgesic profile. Acute pretreatment with HA (5, 10, or 20 mg/kg; i.p.) inhibited the development of mechanical hyperalgesia induced by carrageenan, TNF-α, dopamine and PGE2. Additionally, the immunofluorescence data demonstrated that acute pretreatment with HA, at all doses tested, significantly inhibited Fos-like expression in the spinal cord dorsal horn normally observed after carrageenan-inflammation. Moreover, HA did not affect the motor performance of the mice as tested in the Rota rod test. This antinociceptive profile seems to be related, at least in part, to a reduction of pro-inflammatory cytokines, as IL-1ß. The present results suggest that HA attenuates mechanical hyperalgesia by blocking the neural transmission of pain at the spinal cord levels and by cytokines-inhibitory mechanisms. | pt_BR |
Affilliation | Universidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, SE, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Estadual de Feira de Santana. Colegiado de Ciências Farmacêuticas. Feira de Santana, BA, Brasil | pt_BR |
Affilliation | Universidade Federal do Vale do São Francisco. Colegiado de Ciências Farmacêuticas. Petrolina, PE, Brasil | pt_BR |
Affilliation | Universidade Federal de São João Del-Rei. Curso de Farmácia. Divinópolis, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, SE, Brasil | pt_BR |
Affilliation | Universidade Federal do Piauí. Departamento de Farmácia. Teresina, PI, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, SE, Brasil | pt_BR |
Subject | Hecogenin acetate | pt_BR |
Subject | Steroidal sapogenin | pt_BR |
Subject | Spinal cord | pt_BR |
Subject | C-fos | pt_BR |
Subject | IL-1β | pt_BR |
Subject | Pain | pt_BR |