Author | Badaró, Roberto José da Silva | |
Author | Gonçalves, Larissa Oliveira | |
Author | Gois, Luana Leandro | |
Author | Maia, Zuinara Pereira Gusmão | |
Author | Benson, Constance | |
Author | Grassi, Maria Fernanda Rios | |
Access date | 2014-11-12T19:24:15Z | |
Available date | 2014-11-12T19:24:15Z | |
Document date | 2014 | |
Citation | BADARÓ, R. Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: a literature review. Journal of the InternationalAssociation of Providers of AIDS Care, p. 1-6, 2014. | pt_BR |
ISSN | 2325-9574 | |
URI | https://www.arca.fiocruz.br/handle/icict/8818 | |
Language | eng | pt_BR |
Publisher | Sage Publications | pt_BR |
Rights | open access | pt_BR |
Title | Leishmaniasis as a Manifestation of Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV-Infected Patients: A Literature Review | pt_BR |
Type | Article | pt_BR |
DOI | 10.1177/2325957414555225 | |
Abstract | Introduction: After the onset of highly active antiretroviral therapy (HAART), some HIV-infected patients present a severe
inflammation in response to a latent or a previously treated opportunistic pathogen termed immune reconstitution inflammatory
syndrome (IRIS). Few reports of tegumentary and visceral leishmaniasis have been described in association with IRIS.
Methods: A systematic literature review of IRIS in association with leishmaniasis identified 34 reported cases. Results and
Discussion: The majority of these occurred in males 4 months following the onset of HAART. The mean CD4 count before
HAART was 94 + 77 cells/mm3, increasing to 5 times the initial value between the onset of HAART and IRIS presentation.
Visceral leishmaniasis and post–kala-azar dermal leishmaniasis were the most commonly reported clinical manifestations, followed
by tegumentary leishmaniasis and uveitis. Conclusions: Commonly found characteristics included cutaneous involvement,
regardless of Leishmania species; appearance of lesions unrelated to time of probable Leishmania infection; rapid recovery of
CD4 count following HAART; and rapid progression. | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Prof Edgard Santos. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Prof Edgard Santos. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Faculdade de Medicina. Salvador, BA, BRasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Prof Edgard Santos. Salvador, BA, Brasil | pt_BR |
Affilliation | University of California San Diego. Division of Infectious Diseases. La Jolla, CA, USA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Faculdade de Medicina. Salvador, BA, BRasil | pt_BR |
Subject | HIV/AIDS | pt_BR |
Subject | Immune reconstitution inflammatory syndrome | pt_BR |
Subject | IRIS | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | Co-infection HIV/Leishmania | pt_BR |