Author | Assis, Tália Santana Machado de | |
Author | Braga, Alexandre Sérgio da Costa | |
Author | Pedras, Mariana Junqueira | |
Author | Oliveira, Edward José de | |
Author | Barral, Aldina Maria Prado | |
Author | Siqueira, Isadora Cristina de | |
Author | Costa, Carlos Henrique Nery | |
Author | Costa, Dorcas Lamounier | |
Author | Holanda, Thiago Ayres | |
Author | Soares, Vítor Yamashiro Rocha | |
Author | Silva, Mauro Roberto Biá da | |
Author | Caldas, Arlene de Jesus Mendes | |
Author | Romero, Gustavo Adolfo Sierra | |
Author | Rabello, Ana Lúcia Teles | |
Access date | 2014-12-23T16:53:44Z | |
Available date | 2014-12-23T16:53:44Z | |
Document date | 2011 | |
Citation | ASSIS, T. S. M. et al. Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 105, n. 2, p. 81-85, 2011. | pt_BR |
ISSN | 1878-3503 | |
URI | https://www.arca.fiocruz.br/handle/icict/9289 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | open access | pt_BR |
Title | Multi-centric prospective evaluation of rk39 rapid test and direct agglutination test for the diagnosis of visceral leishmaniasis in Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.trstmh.2010.09.004 | |
Abstract | The diagnosis of visceral leishmaniasis (VL) is still a major problem in Brazil and several other countries where the disease is endemic. The use of an easy-to-use and interpret, sensitive, and specific method that requires no complex infrastructure or specialized professionals, such as direct agglutination test (DAT) and the rK39-based rapid immunochromatographic test may enhance the diagnosis of disease. This study evaluated the performance of a rapid test (DiaMed- IT-LEISH®) and the DAT for the diagnosis of VL in 213 parasitologically confirmed cases and 119 controls with clinical suspicion of VL and confirmation of another etiology. The sensitivities and specificities of the rapid test were 93% and 97%, respectively and those of the DAT were 90% and 96%, respectively. The positive predictive values of the rapid test and the DAT were 98% and 97%, respectively and the negative predictive values were 89% and 84%, respectively. The Kappa index showed agreement between both methods classified as substantial (0.77). This study showed that the DAT and the rapid test can be used to diagnose VL in Brazil, following a pilot study for implementation of the rapid test in the health services | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital da Criança. Obras Sociais de Irmã Dulce. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal do Piauí. Teresina, PI, Brasil | pt_BR |
Affilliation | Universidade Federal do Piauí. Teresina, PI, Brasil | pt_BR |
Affilliation | Universidade Federal do Piauí. Teresina, PI, Brasil | pt_BR |
Affilliation | Universidade Federal do Piauí. Teresina, PI, Brasil | pt_BR |
Affilliation | Universidade Federal do Piauí. Teresina, PI, Brasil | pt_BR |
Affilliation | Universidade Federal do Maranhão. São Luís, MA, Brasil | pt_BR |
Affilliation | Universidade de Brasília. Brasília, DF, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brasil | pt_BR |
Subject | Direct agglutination test | pt_BR |
Subject | Rapid test rK39 | pt_BR |
Subject | Visceral leishmaniasis | pt_BR |
Subject | Sensitivity | pt_BR |
Subject | Specificity and diagnostic accuracy | pt_BR |
DeCS | Testes de Aglutinação/normas | pt_BR |
DeCS | Leishmaniose Visceral/diagnóstico | pt_BR |
DeCS | Kit de Reagentes para Diagnóstico | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Brasil/epidemiologia | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Prevalência | pt_BR |
DeCS | Leishmaniose Visceral/epidemiologia | pt_BR |
DeCS | Estudos Prospectivos | pt_BR |
DeCS | Padrões de Referência | pt_BR |
DeCS | Sensibilidade e Especificidade | pt_BR |