Author | Freitas, Dayvison Francis Saraiva | |
Author | Valle, Antonio Carlos Francesconi do | |
Author | Silva, Margarete Bernardo Tavares da | |
Author | Campos, Dayse Pereira | |
Author | Lyra, Marcelo Rosandiski | |
Author | Souza, Rogerio Valls de | |
Author | Veloso, Valdiléa G. | |
Author | Zancopé-Oliveira, Rosely Maria | |
Author | Bastos, Francisco Inácio Pinkusfeld Monteiro | |
Author | Galhardo, Maria Clara Gutierrez | |
Access date | 2014-12-10T11:49:21Z | pt_BR |
Access date | 2015-01-05T15:49:41Z | |
Available date | 2015-01-05T15:49:41Z | |
Document date | 2014 | |
Citation | FREITAS, Dayvison Francis Saraiva et al. Sporotrichosis: an emerging neglected opportunistic infection in hiv-infected patients in rio de janeiro, brazil. PLoS Neglected Tropical Diseases, v. 8, n. 8, p. 1-8, Aug. 2014. | en_US |
ISSN | 1935-2735 | |
URI | https://www.arca.fiocruz.br/handle/icict/9298 | |
Sponsorship | Financial support was received from FAPERJ/Rio de Janeiro, Brazil (grant proc. E-26/110.619/2012) and PAPES VI – CNPq/Fiocruz (grant proc. 407693/2012-2). DFSF received financial support from CNPq and CAPES. RMZO was supported in part by CNPq (350338/2000-0) and FAPERJ (E-26/103.157/2011). MCGG received partial funding from the Brazilian National STD/AIDS Program, Ministry of Health (46/CV079/2006). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | en_US |
Language | eng | en_US |
Publisher | Public Library of Science | en_US |
Rights | open access | en_US |
Title | Sporotrichosis: an emerging neglected opportunistic infection in HIV-infected patients in Rio de Janeiro, Brazil | en_US |
Type | Article | en_US |
DOI | DOI:10.1371/journal.pntd.0003110 | |
Abstract | Sporotrichosis associated with zoonotic transmission remains a relevant public health problem in Rio de Janeiro, Brazil, affecting a large at-risk population, which includes HIV-infected individuals. We assessed patients co-infected by Sporothrix spp. and HIV over time in the context of an unabated sporotrichosis epidemic. A retrospective cohort retrieved information from a National reference institute for infectious diseases regarding 48 patients with sporotrichosis-HIV co-infection (group 1) as well as 3,570 patients with sporotrichosis (group 2), from 1987 through March 2013. Most patients from group 1 were male (68.8%), whereas women were predominant in group 2 (69.1%; p,0.0001). Patients from group 1 were younger than those from group 2 (m = 38.38610.17 vs. 46.34615.85; p,0.001) and differed from group 2 in terms of their race/ethnic background, with 70.8% non-white patients in group 1 vs. 38.6% from group 2 (p,0.0001). Close to half (,44%) of the patients from group 1 were hospitalized due to sporotrichosis over time, whereas hospitalization was very unlikely in group 2, among whom approximately 1% were hospitalized over time. Dissemination of sporotrichosis was the main cause of hospitalization in both groups, although it was more common among hospitalized patients from group 1 (19/21 [90.5%] vs. 16/37 [43.2%]; p,0.001). Over the period under analysis, eight patients died due to sporotrichosis (3/48 vs. 5/3,570). The diagnosis of sporotrichosis elicited HIV testing and subsequent diagnosis in 19/48 patients, whereas 23/48 patients were simultaneously diagnosed with the two infections. HIV infection aggravates sporotrichosis, with a higher incidence of severe disseminated cases and a higher number of hospitalizations and deaths. Underserved populations, among whom sporotrichosis has been propagated, have been affected by different transmissible (e.g., HIV) and non-transmissible diseases. These populations should be targeted by community development programs and entitled to integrated management and care of their superimposed burdens. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Comunicação e Informação Científica e Tecnológica em Saúde. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
Subject | Sporotrichosis | en_US |
Subject | HIV | en_US |
Subject | HIV-Infected Patients | en_US |
Subject | Public health | en_US |
Subject | Sporotrichosis epidemic | en_US |
Subject | Subcutaneous mycosis | en_US |