Author | Moreira Júnior, Edson Duarte | |
Author | Nassri, Victor Bastos | |
Author | Santos, Rafaela Sousa | |
Author | Matos, Junísia Ferraz | |
Author | Carvalho, Wilson Andrade de | |
Author | Silvani, Célia Stolve | |
Author | Sant’Ana, Círia Santana e | |
Access date | 2015-03-25T16:19:42Z | |
Available date | 2015-03-25T16:19:42Z | |
Document date | 2005 | |
Citation | MOREIRA JÚNIOR, E. D. et al. Association of Helicobacter pylori infection and giardiasis: results from a study of surrogate markers for fecal exposure among children. World Journal of Gastroenterology, v. 11, n. 18, p. 2759-2763 , 2005. | pt_BR |
ISSN | 1007-9327 | |
URI | https://www.arca.fiocruz.br/handle/icict/9827 | |
Language | eng | pt_BR |
Publisher | The WJG Press and Elsevier Inc. | pt_BR |
Rights | open access | pt_BR |
Title | Association of Helicobacter pylori infection and giardiasis: results from a study of surrogate markers for fecal exposure among children. | pt_BR |
Type | Article | pt_BR |
Abstract | AIM: To investigate whether Helicobacter pylori (H pylori) infection is associated with hepatitis A virus (HAV) infection, presence of enteroparasites, and other surrogates of fecal exposure. METHODS: We conducted a cross-sectional study in 121 children consecutively admitted at a pediatric hospital in Salvador, Brazil. H pylori and HAV infection were identified by the presence of serum antibodies. Stool specimens were examined for the presence of ova and parasites. A structured questionnaire inquiring about sanitary conditions and life style was applied to each subject. RESULTS: Fifty-one of the 121 children (42.1%) were found to be seropositive for H pylori, and 45 (37.2%) for HAV. The seroprevalence of H pylori and HAV both increased significantly with age. Cross-tabulation of data showed that 26 (21.5%) were seropositive and 51 (42.1%) were negative for both H pylori and HAV antibodies (chi(2) = 7.18, OR = 2.8, CI 1.30-5.97). The age adjusted OR for an HAV-infected child being H pylori positive was 2.3 (CI 1.02-5.03). The agreement between H pylori and HAV seropositivity was fair (kappa = 0.24). After controlling for possible confounding, the variables remaining independently associated with seropositivity to H pylori were age, presence of Giardia lamblia in feces (OR = 3.2, 95%CI, 1.1-9.5) and poor garbage disposal quality (OR = 2.4, 95%CI, 1.1-5.1). CONCLUSION: Our data suggest that H pylori infection is associated with surrogate markers of fecal exposure. Thus, we conclude that the fecal-oral route is relevant in the transmission of HP among children in an urban setting of a developing country. The association observed between G. lamblia and H pylori infection may have several explanations. Further studies to investigate this relationship are warranted. | pt_BR |
Affilliation | Fundação Irmã Dulce. Núcleo de Apoio à Pesquisa. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael, Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Irmã Dulce. Núcleo de Apoio à Pesquisa. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael, Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Irmã Dulce. Núcleo de Apoio à Pesquisa. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael, Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital São Rafael, Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital São Rafael, Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Irmã Dulce. Núcleo de Apoio à Pesquisa. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Irmã Dulce. Núcleo de Apoio à Pesquisa. Salvador, BA, Brasil | pt_BR |
Subject | H pylori | pt_BR |
Subject | Hepatitis A virus | pt_BR |
Subject | Epidemiology | pt_BR |
Subject | Transmission | pt_BR |
Subject | Enteroparasites | pt_BR |
Subject | Brazil | pt_BR |
DeCS | Giardíase/complicações | pt_BR |
DeCS | Infecções por Helicobacter/complicações | pt_BR |
DeCS | Helicobacter pylori | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Brasil | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Pré-Escolar | pt_BR |
DeCS | Estudos Transversais | pt_BR |
DeCS | Países em Desenvolvimento | pt_BR |
DeCS | Fezes/parasitologia | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Giardia lamblia/isolamento & purificação | pt_BR |
DeCS | Infecções por Helicobacter/transmissão | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Lactente | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | População Urbana | pt_BR |