Browsing by Author "Podust, Larissa M."
Now showing items 1-10 of 10
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4-Aminopyridyl-Based CYP51 Inhibitors as Anti-Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency
Calvet, C. M. et al. | Date Issued: 2014 -
4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection
Calvet, Claudia Magalhaes et al. | Date Issued: 2017 -
Binding Mode and Potency of N‑Indolyloxopyridinyl-4- aminopropanyl-Based Inhibitors Targeting Trypanosoma cruzi CYP51
Vieira, Debora F. et al. | Date Issued: 2014 -
Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents
Saccoliti, Francesco et al. | Date Issued: 2018 -
Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target
Choy, Jonathan W. et al. | Date Issued: 2013 -
CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)
Debnath, Anjan et al. | Date Issued: 2017 -
Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents
Saccoliti, Francesco et al. | Date Issued: 2019 -
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51
Gunatilleke, Shamila S. et al. | Date Issued: 2012 -
Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast
Ottilie, Sabine et al. | Date Issued: 2017 -
Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents
Choi, Jun Yong et al. | Date Issued: 2013