| Author | Coelho, Lara Esteves | |
| Author | Veloso, Valdiléa G. | |
| Author | Grinsztejn, Beatriz | |
| Author | Luz, Paula Mendes | |
| Access date | 2015-04-15T17:00:51Z | |
| Available date | 2015-04-15T17:00:51Z | |
| Document date | 2014 | |
| Citation | COELHO, Lara Esteves et al. Trends in overall opportunistic illnesses, pneumocystis cariniipneumonia, cerebral toxoplasmosis and mycobacteriumavium complex incidence rates over the 30 years of the HIV epidemic: a systematic review. Brazilian Journal of Infectious Diseases, Salvador, v. 18, n. 2, p. 196-210, 2014. | pt_BR |
| ISSN | 1413-8670 | |
| URI | https://www.arca.fiocruz.br/handle/icict/10006 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Title | Trends in overall opportunistic illnesses, pneumocystis cariniipneumonia, cerebral toxoplasmosis and mycobacteriumavium complex incidence rates over the 30 years of the HIV epidemic: a systematic review | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.bjid.2013.10.003 | |
| Abstract | Background: The natural history of HIV infection has changed dramatically after theintroduction of highly active antiretroviral therapy. Currently, opportunistic illnesses stillrepresent a major cause of death and hospitalization in this population. In this study,we review the trends in opportunistic illnesses incidence rates and compare the resultsobserved in high-income settings with that for low/middle-income settings, with specialattention given to studies from Brazil.Methods: We systematically searched Pubmed, Web of Science, Lilacs and Google scholarfor publications on HIV associated opportunistic illness. Studies reporting rates based onperson-time for all opportunistic illnesses and/or the three opportunistic infections ofinterest, namely, Pneumocystis carinii pneumonia, cerebral toxoplasmosis, and Mycobacteriumavium complex were included.Results: Significant reductions in the incidence rates were demonstrated for opportunisticillnesses overall and also for the specific opportunistic infections included in the presentstudy, both in high and low/middle-income settings. Out of the 37 studies included in thepresent review, almost 70% were from high-income settings. All the studies conducted inlow/middle-income settings were single center studies and four were from Brazil. We foundno study from Brazil reporting annual incidence rates of opportunistic illnesses.Conclusions: Opportunistic illnesses remain an important public health problem. To betterguide health policies in low/middle-income settings, multicenter cohort studies should beencouraged. Studies from Brazil are urgently needed to assess the current burden of oppor-tunistic illnesses in our population and to support the planning of HIV/AIDS health careservices organization. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Subject | AIDS-related opportunistic | |
| Subject | Infections | |
| Subject | Opportunistic infection | |
| Subject | Acquired immunodeficiency | |
| Subject | Syndrome | |
| Subject | Incidence | |
| DeCS | AIDS-Related Opportunistic Infections | pt_BR |
| DeCS | Opportunistic Infections | pt_BR |
| DeCS | Acquired Immunodeficiency Syndrome | pt_BR |
| DeCS | Syndrome | pt_BR |
| DeCS | Incidence | pt_BR |
| e-ISSN | 1678-4391 | |
