| Author | Nair, Divya K | |
| Author | Menna-Barreto, F. S | |
| Author | Silva Junior, Eufrânio N. da | |
| Author | Mobin, Shaikh M | |
| Author | Namboothiri, Irishi N. N | |
| Access date | 2015-04-17T17:04:30Z | |
| Available date | 2015-04-17T17:04:30Z | |
| Document date | 2014 | |
| Citation | NAIR, Divya K et al. Chiral squaramide-catalyzed asymmetric synthesis of pyranones and pyranonaphthoquinones via cascade reactions of 1,3-dicarbonyls with Morita–Baylis–Hillman acetates of nitroalkenes. Chem. Commun.,n.50, p. 6973-6976, 2014. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/10061 | |
| Language | eng | pt_BR |
| Publisher | Royal Society of Chemestry | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Trypanosoma cruzi, | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Title | Chiral squaramide-catalyzed asymmetric synthesis of pyranones and pyranonaphthoquinones via cascade reactions of 1,3-dicarbonyls with Morita–Baylis–Hillman acetates of nitroalkenes | pt_BR |
| Type | Article | |
| DOI | 10.1039/c4cc02279c | pt_BR |
| Abstract | Cascade reactions of 1,3-dicarbonyls with Morita–Baylis–Hillman acetates of nitroalkenes using a quinine derived chiral squaramide organocatalyst led to the formation of pyranones and pyranonaphthoquinones in good to excellent yields and high diastereo- and enantioselectivities. Representative examples of the reaction scale-up with a much lower catalyst loading without an appreciable loss of selectivities and synthetic transformations of the products are also reported here. The compounds described herein for the first time were evaluated against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease, since the structures are related to bioactive α-lapachones. | pt_BR |
| Affilliation | Indian Institute of Technology Bombay. Department of Chemistry. Mombai, India. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Química. Instituto de Ciências Exatas. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Indian Institute of Technology Bombay.National Single-Crystal X-Ray Diffraction Facility. Mumbai, India. | pt_BR |
| Affilliation | Indian Institute of Technology Bombay. Department of Chemistry. Mombai, India. | pt_BR |
| Subject | Trypanosoma cruzi, | pt_BR |
| Subject | Chagas Disease | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
