| Author | Demarque, Kelly Cristina | |
| Author | Rangel, Janaína Alves | |
| Author | Kuzel, Maria Alice do Amaral | |
| Author | Rodriques, Frederico Villas Boas | |
| Author | Oliveira, Fernanda da Silva | |
| Author | Alvarenga, Tathiana A. | |
| Author | Andersen, Monica L. | |
| Author | Tufik, Sergio Batista | |
| Author | Silva, Wanderson | |
| Author | Gameiro, Lucas dos Santos | |
| Author | Oliveira, Gabriel Melo de | |
| Access date | 2015-04-17T17:04:34Z | |
| Available date | 2015-04-17T17:04:34Z | |
| Document date | 2013 | |
| Citation | DEMARQUE, Kelly Cristina et al. Total testosterone/progesterone rate and appearance of spontaneous aggressive behavior in male swiss webster mice. RESBCAL, v.2, n.3, p. 206-216, 2013 | pt_BR |
| ISSN | 2238-1589 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/10075 | |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Ciência em Animais de Laboratório (RESBCAL) | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Camundongos | pt_BR |
| Subject in Portuguese | Progesterona | pt_BR |
| Subject in Portuguese | Violência | pt_BR |
| Subject in Portuguese | Testosterona | pt_BR |
| Subject in Portuguese | Comportamento Agressivo | pt_BR |
| Title | Estudo sobre a relação entre testoterona/progesterone e o surgimento de comportamento agressivo de camundongos machos da linhagem Swiss Webster | pt_BR |
| Title | Total testosterone/progesterone rate and appearance of spontaneous aggressive behavior in male Swiss Webster mice | pt_BR |
| Type | Article | |
| Abstract | Violence is a serious public health problem and has a high impact on the quality of life of
individuals across societies. Evolutionary, genetic, environmental, and cultural factors are
closely interconnected as morbid causes. Animal models can be an important tool in the
study of aggression. Regrouped Swiss Webster mice were selected based on mobility
profile (Hypo, Normal; Hyper), which was defined by the tail suspension test. Our results
demonstrate that Hyper mice (anxiety-like behavior) were more aggressive and violent
than the other two categories, indicated by a pattern of aggressive behavior with a score
4+ in relation to score 1+ of Normal category. Hyper group, showed a decrease in total
testosterone levels (-32.5% in relation to Norm group) and an increase in progesterone
levels (+57.6% compared with the Norm group). We also observed a decrease in the
weight of the testicles, the seminiferous tubules, Leydig and diploid spermatogenic
cells number in hyper aggressive animals. Together, the results indicate an association
between testosterone/progesterone and the appearance of highly aggressive behavior
in male Swiss Webster mice. CEUA/FIOCRUZ, #LW-5/12. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal de São Paulo/UNIFESP. Departamento de Psicobiologia. São Paulo, SP, 2014. | pt_BR |
| Affilliation | Universidade Federal de São Paulo/UNIFESP. Departamento de Psicobiologia. São Paulo, SP, 2014. | pt_BR |
| Affilliation | Universidade Federal de São Paulo/UNIFESP. Departamento de Psicobiologia. São Paulo, SP, 2014. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Biofilmes. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil | pt_BR |
| Subject | Mice | pt_BR |
| Subject | Aggressive Behavior | pt_BR |
| Subject | Sexual Hormones | pt_BR |
| Subject | Testosterone | pt_BR |
| Subject | Progesterone | pt_BR |
| Subject | Violence | pt_BR |
| Subject | Males | pt_BR |
| xmlui.metadata.dc.subject.ods | 16 Paz, Justiça e Instituições Eficazes | |
