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AutorLima, Valdirene dos Santos
AutorJansen, Ana Maria
AutorMessenger, Louisa A
AutorMiles, Michael A
AutorLlewellyn, Martin S
Fecha de acceso2015-04-22T14:23:06Z
Fecha de disponibilización2015-04-22T14:23:06Z
Fecha de publicación2014
ReferenciaLIMA, Valdirene S. et al. Wild Trypanosoma cruzi I genetic diversity in Brazil suggests admixture and disturbance in parasite populations from the Atlantic Forest region. Parasites & Vectors, v.7, n.263, 8p, 2014.pt_BR
ISSN1756-3305pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/10091
Idiomaengpt_BR
EditorBioMed Centralpt_BR
Derechos de autoropen access
Palabras clave en PortuguésTrypanosoma cruzipt_BR
Palabras clave en PortuguésParasitospt_BR
Palabras clave en PortuguésBrasilpt_BR
TítuloWild Trypanosoma cruzi I genetic diversity in Brazil suggests admixture and disturbance in parasite populations from the Atlantic Forest regionpt_BR
Tipo del documentoArticle
DOI10.1186/1756-3305-7-263pt_BR
Resumen en InglésBackground: Trypanosoma cruzi (Kinetoplastida, Trypanosomatidae) infection is an ancient and widespread zoonosis distributed throughout the Americas. Ecologically, Brazil comprises several distinct biomes: Amazonia, Cerrado, Caatinga, Pantanal and the Atlantic Forest. Sylvatic T. cruzi transmission is known to occur throughout these biomes, with multiple hosts and vectors involved. Parasite species-level genetic diversity can be a useful marker for ecosystem health. Our aims were to: investigate sylvatic T. cruzi genetic diversity across different biomes, detect instances of genetic exchange, and explore the possible impact of ecological disturbance on parasite diversity at an intra-species level. Methods: We characterised 107 isolates of T. cruzi I (TcI; discrete typing unit, DTU I) from different major Brazilian biomes with twenty-seven nuclear microsatellite loci. A representative subset of biologically cloned isolates was further characterised using ten mitochondrial gene loci. We compared these data generated from Brazilian TcI isolates from around America. Results: Genetic diversity was remarkably high, including one divergent cluster that branched outside the known genetic diversity of TcI in the Americas. We detected evidence for mitochondrial introgression and genetic exchange between the eastern Amazon and Caatinga. Finally, we found strong signatures of admixture among isolates from the Atlantic Forest region by comparison to parasites from other study sites. Conclusions: Atlantic Forest sylvatic TcI populations are highly fragmented and admixed by comparison to others around Brazil. We speculate on: the possible causes of Atlantic Forest admixture; the role of T. cruzi as a sentinel for ecosystem health, and the impact disrupted sylvatic transmission cycles might have on accurate source attribution in oral outbreaks.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasilpt_BR
AfiliaciónLondon School of Hygiene and Tropical Medicine. Faculty of Infectious and Tropical Diseases. London, UK.pt_BR
AfiliaciónLondon School of Hygiene and Tropical Medicine. Faculty of Infectious and Tropical Diseases. London, UK.pt_BR
AfiliaciónLondon School of Hygiene and Tropical Medicine. Faculty of Infectious and Tropical Diseases. London, UK / Bangor University. School of Biological Sciences. Molecular Ecology and Fisheries Genetics laboratory. Gwynedd, UK.pt_BR
Palavras clave en InglêsTrypanosoma cruzipt_BR
Palavras clave en InglêsBrazilpt_BR
Palavras clave en InglêsParasitespt_BR
Palavras claveTrypanosoma cruzipt_BR
Palavras claveBrasilpt_BR
Palavras claveParásitospt_BR


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