| Author | Freitas, Rafael Maciel de | |
| Author | Avendanho, Fernando Campos | |
| Author | Santos, Rosangela | |
| Author | Sylvestre, Gabriel | |
| Author | Araújo, Simone Costa | |
| Author | Lima, José Bento Pereira | |
| Author | Martins, Ademir Jesus | |
| Author | Coelho, Giovanni Evelim | |
| Author | Valle, Denise | |
| Access date | 2015-05-04T17:07:28Z | |
| Available date | 2015-05-04T17:07:28Z | |
| Document date | 2014 | |
| Citation | FREITAS, Rafael Maciel de et al. Undesirable Consequences of Insecticide Resistance following Aedes aegypti Control Activities Due to a Dengue Outbreak. Plos One, v.9, n.3, 9p, 2014. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/10199 | |
| Language | eng | pt_BR |
| Publisher | Instituto Pasteur | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Aedes | pt_BR |
| Subject in Portuguese | Dengue | pt_BR |
| Subject in Portuguese | Insecticide Resistance | pt_BR |
| Title | Undesirable Consequences of Insecticide Resistance following Aedes aegypti Control Activities Due to a Dengue Outbreak | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0092424 | pt_BR |
| Abstract | Background: During a dengue outbreak with co-circulation of DENV-1 and -2 in the city of Boa Vista, one patient was
diagnosed with DENV-4, a serotype supposed absent from Brazil for almost 30 years. The re-emergence of DENV-4 triggered
the intensification of mechanical and chemical Aedes aegypti control activities in order to reduce vector density and avoid
DENV-4 dissemination throughout the country.
Methods/Principal Findings: Vector control activities consisted of (a) source reduction, (b) application of diflubenzuron
against larvae and (c) vehicle-mounted space spraying of 2% deltamethrin to eliminate adults. Control activity efficacy was
monitored by comparing the infestation levels and the number of eggs collected in ovitraps before and after interventions,
performed in 22 Boa Vista districts, covering an area of ,80% of the city and encompassing 56,837 dwellings. A total of
94,325 containers were eliminated or treated with diflubenzuron. The most frequently positive containers were small
miscellaneous receptacles, which corresponded to 59% of all positive breeding sites. Insecticide resistance to deltamethrin
was assessed before, during and after interventions by dose-response bioassays adopting WHO-based protocols. The
intense use of the pyrethroid increased fourfold the resistance ratio of the local Ae. aegypti population only six months after
the beginning of vector control. Curiously, this trend was also observed in the districts in which no deltamethrin was
applied by the public health services. On the other hand, changes in the resistance ratio to the organophosphate temephos
seemed less influenced by insecticide in Boa Vista.
Conclusions: Despite the intense effort, mosquito infestation levels were only slightly reduced. Besides, the median number
of eggs in ovitraps remained unaltered after control activity intensification. The great and rapid increase in pyrethroid
resistance levels of natural Ae. aegypti populations is discussed in the context of both public and domestic intensification of
chemical control due to a dengue outbreak. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil. | pt_BR |
| Affilliation | Secretaria Estadual de Saúde de Roraima. Boa Vista, RR, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (INCT-EM), Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (INCT-EM), Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Aedes aegypti | pt_BR |
| Subject | Dengue | pt_BR |
| Subject in Spanish | Aedes | pt_BR |
| Subject in Spanish | Dengue | pt_BR |
