Author | Santos, Luciano Cincurá Silva | |
Author | Ramos, Eduardo Antônio Gonçalves | |
Author | Gurgel, Clarissa Araújo Silva | |
Author | Santana, Edmar José Borges de | |
Author | Santos, Jean Nunes dos | |
Access date | 2015-05-05T17:36:10Z | |
Available date | 2015-05-05T17:36:10Z | |
Document date | 2007 | |
Citation | SANTOS, L. C. et al. Immunohistochemical detection of Langerhans cells in dental granulomas and radicular cysts. Journal of Molecular Histology, v. 38, n. 3, p. 201-205, 2007. | pt_BR |
ISSN | 1567-2379 | |
URI | https://www.arca.fiocruz.br/handle/icict/10243 | |
Language | eng | pt_BR |
Publisher | Springer Verlag | pt_BR |
Rights | open access | pt_BR |
Title | Immunohistochemical detection of Langerhans cells in dental granulomas and radicular cysts. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1007/s10735-007-9088-3 | |
Abstract | Objective Dental granulomas (DGs) and radicular cysts
(RCs) are chronic periapical lesions frequently involving
the jaws. Langerhans cells (LCs) are dendritic cells
responsible for the presentation of antigens to T lymphocytes.
This study examined the expression of LCs in DG
and RCs by immunohistochemical staining.
Study Design Eighteen cases of DGs and 26 cases of RCs
were analyzed using anti-CD1a marker.
Results CD1a-labeled LCs were observed in 11.1% of
DGs and in 69.2% of RCs, showing a significant correlation
(P < 0.0001; Fisher’s test). In DGs, LCs were only
observed in granulation tissue, showing discrete immunostaining
density. In RCs, LCs exhibited both a round and a
dendritic shape in all epithelial layers. Although a correlation
was observed between immunostaining density and
epithelial thickness, as well as between immunostaining
and inflammatory intensity, the differences were not significant
in radicular cysts. | pt_BR |
Affilliation | Universidade Federal da Bahia. Escola de Dentista. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Histopatologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Histopatologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Escola de Dentista. Laboratorio de Patologia Oral. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Escola de Dentista. Laboratorio de Patologia Oral. Salvador, BA, Brasil | pt_BR |
Subject | Radicular cyst | pt_BR |
Subject | Dental granuloma | pt_BR |
Subject | Immunohistochemistry | pt_BR |
Subject | Langerhans cell | pt_BR |
DeCS | Células de Langerhans/imunologia | pt_BR |
DeCS | Granuloma Periapical/imunologia | pt_BR |
DeCS | Cisto Radicular/imunologia | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Idoso | pt_BR |
DeCS | Antígenos CD1/imunologia | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Pré-Escolar | pt_BR |
DeCS | Femenino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Imuno-Histoquímica | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Granuloma Periapical/patologia | pt_BR |
DeCS | Cisto Radicular/patologia | pt_BR |