| Author | Alves, Luiz Anastácio | |
| Author | Reis, Ricardo Augusto de Melo | |
| Author | Souza, Cristina Alves Magalhães de | |
| Author | Freitas, Monica Santos de | |
| Author | Teixeira, Pedro Celso Nogueira | |
| Author | Ferreira, Dinarte Neto Moreira | |
| Author | Xavier, Robson Faria | |
| Access date | 2015-05-08T14:08:44Z | |
| Available date | 2015-05-08T14:08:44Z | |
| Document date | 2014 | |
| Citation | ALVES, Luiz Anastacio et al. The P2X7 receptor: Shifting from a low- to a high-conductance channel — An enigmatic phenomenon?. Biochimica et Biophysica Acta, v.1838,n.10, p.2578–2587, 2014. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/10261 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Title | The P2X7 receptor: Shifting from a low- to a high-conductance channel — An enigmatic phenomenon? | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.bbamem.2014.05.015 | pt_BR |
| Abstract | The general structure of the P2X7 receptor (P2X7R) is similar to the structure of other P2X receptor family
members, with the exception of its C terminus, which is the longest of this family. The P2X7R activates several
intracellular signaling cascades, such as the calmodulin, mitogen-activated protein kinase and phospholipase
D pathways. At low concentrations of ATP (micromolar range), P2X7R activation opens a cationic channel, similarly
to other P2X receptors. However, in the presence of high concentrations of ATP (millimolar range), it opens
a pathway that allows the passage of larger organic cations and anions. Here,we discuss both the structural characteristics
of P2X7R related to its remarkable functions and the proposed mechanisms, including the dilation of
the endogenous pore and the integration of another channel. In addition, we highlight the importance of
P2X7R as a therapeutic target. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto Nacional de Ciências e Tecnologia de Biologia Estrutural e Bioimagem. Instituto de Bioquímica Médica. Centro Nacional de Ressonância Magnética Nuclear Jiri Jonas. Rio de Janeiro, Rj, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | P2X7R | pt_BR |
| Subject | Ion channel activity | pt_BR |
| Subject | Patch-clamp | pt_BR |
| Subject | Calcium | pt_BR |
| Subject | Second messenger | pt_BR |
