| Author | Santos, Itamar S | |
| Author | Brunoni, André R | |
| Author | Goulart, Alessandra C | |
| Author | Griep, Rosane Harter | |
| Author | Lotufo, Paulo A | |
| Author | Bensenor, Isabela M | |
| Access date | 2015-05-15T13:16:40Z | |
| Available date | 2015-05-15T13:16:40Z | |
| Document date | 2014 | |
| Citation | SANTOS, Itamar s. et al. Negative life events and migraine: a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline data. BMC Public Health, v.14, n. 678, 10p, 2014. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/10315 | |
| Language | eng | pt_BR |
| Publisher | Biomed Central | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Enxaqueca | pt_BR |
| Subject in Portuguese | Epidemiologia | pt_BR |
| Title | Negative life events and migraine: a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline data | pt_BR |
| Type | Article | |
| DOI | 10.1186/1471-2458-14-678 | pt_BR |
| Abstract | Background: Stress is a typical migraine trigger. However, the impact of negative life events on migraine activity is
poorly studied. The aim of this study is to investigate the association between negative life events and migraine
using data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline assessment.
Methods: ELSA-Brasil is a multicenter cohort study conducted in six Brazilian cities. Baseline assessment included
validated questionnaires for headache classification and the occurrence of five pre-specified negative life events
(financial hardship, hospitalization other than for childbirth, death of a close relative, robbery and end of a love
relationship), focusing on a 12-month period before evaluation. We built crude and adjusted logistic regression models
to study the association between the occurrences of negative life events and migraine diagnosis and activity.
Results: We included 4,409 individuals with migraine and 4,457 participants without headache (reference). After
adjustment for age, sex, race, income and educational level, we found that the occurrence of a negative life event
(Odds ratio = 1.31; 95% confidence interval = 1.19 – 1.45) was associated with migraine. However, after stratifying with
subgroup analyses, only financial hardship (Odds ratio = 1.65; 95% confidence interval = 1.47 – 1.87) and hospitalization
(Odds ratio = 1.47; 95% confidence interval = 1.25 – 1.72) were independently associated with migraine. Further
adjustment for a current major depression episode and report of religious activity did not significantly change the
results. Considering migraine frequency as (a) less than once per month, (b) once per month to once per week, or (c)
more than once per week, financial hardship and hospitalization remained significantly associated with migraine in all
episode frequency strata, with higher odds ratios for higher frequencies in adjusted models. We also observed a
significant association between the death of a close relative and the highest migraine frequency stratum (Odds ratio =
1.38; 95% confidence interval = 1.09 – 1.75) in full-adjusted model.
Conclusions: The occurrence of financial hardship and hospitalization had a direct and independent association with
migraine diagnosis and frequency. The death of a close relative was also independently associated with the highest
migraine frequency stratum. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Departamento de Clínica Médica. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Departamento de Clínica Médica. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Departamento de Clínica Médica. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | pt_BR |
| Subject | Migraine | pt_BR |
| Subject | Life events | pt_BR |
| Subject | Epidemiology | pt_BR |
| Subject | Cross-sectional | pt_BR |
| Subject | Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) | pt_BR |
| Subject | Negative life events | pt_BR |
