| Author | Andrade, Bruno Gabriel Nascimento | |
| Author | Marin, Michel F. Abanto | |
| Author | Cambuy, Diego Duque | |
| Author | Fonseca, Erica Lourenço | |
| Author | Souza, Nadjila Ferreira | |
| Author | Vicente, Ana Carolina P. | |
| Access date | 2015-05-19T13:26:09Z | |
| Available date | 2015-05-19T13:26:09Z | |
| Document date | 2014 | |
| Citation | ANDRADE, Bruno Gabriel N. et al. Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 7, p. 952-954, nov. 2014. | pt_BR |
| ISSN | 1678-8060 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/10415 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1590/0074-0276140288 | pt_BR |
| Abstract | There has been a resurgence in the number of pertussis cases in Brazil and around the world. Here, the genome of a clinical Bordetella pertussis strain (Bz181) that was recently isolated in Brazil is reported. Analysis of the virulence-associated genes defining the pre- and post-vaccination lineages revealed the presence of the prn2-ptxS1A-fim3B-ptxP3 allelic profile in Bz181, which is characteristic of the current pandemic lineage. A putative metallo-β-lactamase gene presenting all of the conserved zinc-binding motifs that characterise the catalytic site was identified, in addition to a multidrug efflux pump of the RND family that could confer resistance to erythromycin, which is the antibiotic of choice for treating pertussis disease. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular e Microorganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular e Microorganismos. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular e Microorganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular e Microorganismos. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Laboratório Central de Saúde Pública Dr Milton Sobral. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular e Microorganismos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | ptxP3 | pt_BR |
| Subject | Pandemic lineage | pt_BR |
| Subject | Virulence factors | pt_BR |
| Subject | Antigenic variant | pt_BR |
| DeCS | Fatores de Virulência | pt_BR |
| DeCS | Bordetella pertussis | pt_BR |
