Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10445
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dc.contributor.authorBernardino, Alice Maria Rolim
dc.contributor.authorPinheiro, Luiz Carlos da Silva
dc.contributor.authorRodrigues, Carlos Rangel
dc.contributor.authorLoureiro, Natália Izabel
dc.contributor.authorCastro, Helena Carla
dc.contributor.authorRangel, Adriana Lanfredi
dc.contributor.authorLopes, Juliano Sabatini
dc.contributor.authorBorges, Júlio César
dc.contributor.authorCarvalho, Jane Maria
dc.contributor.authorRomeiro, Gilberto Alves
dc.contributor.authorFerreira, Vitor Francisco
dc.contributor.authorFrugulhetti, Izabel C. P. P
dc.contributor.authorSantos, Marcos André Vannier dos
dc.date.accessioned2015-05-20T18:54:34Z
dc.date.available2015-05-20T18:54:34Z
dc.date.issued2006
dc.identifier.citationBERNARDINO, A. M. R. Design, synthesis, SAR, and biological evaluation of new 4-(phenylamino)thieno[2,3-b]pyridine derivatives. Bioorganic & Medicinal Chemistry, v. 14, n. 16, p. 5765-5770, 2006.
dc.identifier.issn0968-0896
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/10445
dc.language.isoeng
dc.publisherElsevier
dc.rightsopen access
dc.titleDesign, synthesis, SAR, and biological evaluation of new 4-(phenylamino)thieno[2,3-b]pyridine derivatives
dc.typeArticle
dc.identifier.doi10.1016/j.bmc.2006.03.013
dc.description.abstractenIn this work, we performed the design, synthesis, and the structure–activity relationship studies of 13 new derivatives of thieno[2,3-b]pyridine. These derivatives were prepared in high yields (96–70%) and their structures were elucidated by IR, 1H, 13C NMR, and MS. The biological results showed some derivatives as antiparasitic agents against Giardia lamblia. Computational analysis of HOMO and LUMO energy, HOMO orbital coefficient distribution, electrostatic potential map, dipole moment, and density HOMO was performed to gain insight into the SAR aspects. This study pointed the p-methoxy substituted derivative as a leading compound for the development of new microbicidal medicines based on thieno[2,3-b]pyridine analogs
dc.creator.affilliationUniversidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Niterói, RJ, Brasil
dc.creator.affilliationUniversidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Niterói, RJ, Brasil
dc.creator.affilliationUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Rio de Janeiro, RJ, Brasil
dc.creator.affilliationUniversidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil
dc.creator.affilliationUniversidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Niterói, RJ, Brasil
dc.creator.affilliationUniversidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Niterói, RJ, Brasil
dc.creator.affilliationUniversidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Niterói, RJ, Brasil
dc.creator.affilliationUniversidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Niterói, RJ, Brasil
dc.creator.affilliationUniversidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
dc.subject.decsAminopiridinas
dc.subject.decsAntiprotozoários
dc.subject.decsGiardia lamblia
dc.subject.decsTiofenos
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