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AutorMarques, Suzane M.
AutorCastro, Pollyana R.
AutorCampos, Paula Peixoto
AutorViana, Celso Tarso Rodrigues
AutorParreiras, Patricia Martins
AutorFerreira, Mônica Alves Neves Diniz
AutorAndrade, Silvia Passos
Data de acesso2015-05-25T18:40:45Z
Data de disponibilização2015-05-25T18:40:45Z
Data do publicação2014
CitaçãoMARQUES, Suzane M. et al. Genetic strain differences in the development of peritoneal fibroproliferative processes in mice. Wound Rep Reg, v. 22, p. 381–389, 2014pt_BR
ISSN1524-475X
URIhttps://www.arca.fiocruz.br/handle/icict/10495
Idiomaengpt_BR
EditorWound Healing Societypt_BR
Direito Autoralrestricted accesspt_BR
TítuloGenetic strain differences in the development of peritoneal fibroproliferative processes in micept_BR
Tipo do documentoArticle
DOI10.1111/wrr.12177
Resumo em InglêsFibroproliferative processes are regulated by a wide variety of tissue components and genetic factors. However, whether there are genetic differences in peritoneal fibroproliferative tissue formation, with consequent differences in response to drug treatment, is unclear. We characterize the influence of the genetic background on peritoneal fibroproliferative tissue induced by sponge implants in DBA/1, Swiss, C57BL/6, and BALB/c mouse strains. In addition, responses to dipyridamole in the implants were evaluated. Angiogenesis, assessed by intra-implant hemoglobin content, was highest in Swiss mice, whereas levels of vascular endothelial growth factor were highest in C57BL/6 mice. The levels of pro-inflammatory cytokines and of inflammatory enzymes (myeloperoxidase- and N-acetyl-β-D-glucosaminidase) were also strain-related. The pro-fibrogenic markers transforming growth factor beta-1 and collagen were lowest in implants placed in DBA/1 mice, whereas those in C57BL/6 mice had the highest levels. Differential sensitivity to dipyridamole was also observed, with this compound being pro-angiogenic in implants placed in DBA/1 mice but antiangiogenic in implants placed in Swiss. An overall anti-inflammatory response was observed in the inbred strains. Antifibrogenic effects were observed only in implants placed in C57BL/6 mice. These important strainrelated differences in the development of peritoneal fibrosis and in response to dipyridamole must be considered in the design and analysis of studies on fibrogenesis in mice.pt_BR
AfiliaçãoUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Fisiologia e Biofisica. Belo Horizonte, MG, Brasilpt_BR
AfiliaçãoUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Fisiologia e Biofisica. Belo Horizonte, MG, Brasilpt_BR
AfiliaçãoUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brasilpt_BR
AfiliaçãoUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Fisiologia e Biofisica. Belo Horizonte, MG, Brasilpt_BR
AfiliaçãoFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasilpt_BR
AfiliaçãoUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Patologia Geral. Belo Horizonte, MG, Brasilpt_BR
AfiliaçãoUniversidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Fisiologia e Biofisica. Belo Horizonte, MG, Brasilpt_BR
Palavras-chave em inglêsAngiogenesis Inhibitors/pharmacologypt_BR
Palavras-chave em inglêsMice, Inbred BALB Cpt_BR
Palavras-chave em inglêsWound Healing/immunologypt_BR
Palavras-chave em inglêsNeovascularizationpt_BR


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