| Author | Carvalho, Amanda Torrentes | |
| Author | Marinho, Cintia Ferreira | |
| Author | Pinto, Luzia Maria de Oliveira | |
| Author | Oliveira, Débora Batista de | |
| Author | Damasco, Paulo Vieira | |
| Author | Cunha, Rivaldo Venâncio | |
| Author | Souza, Luiz José de | |
| Author | Azeredo, Elzinandes Leal de | |
| Author | Kubelka, Claire Fernandes | |
| Access date | 2015-05-27T13:39:44Z | |
| Available date | 2015-05-27T13:39:44Z | |
| Document date | 2014 | |
| Citation | CARVALHO, Amanda Torrentes et al. Regulation of T lymphocyte apoptotic markers is associated to cell activation during the acute phase of dengue. Immunobiology, v.219, n.5, p.329–340, May 2014. | pt_BR |
| ISSN | 0171-2985 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/10526 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | MArcadores | pt_BR |
| Title | Regulation of T lymphocyte apoptotic markers is associated to cellactivation during the acute phase of dengue | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.imbio.2013.11.002 | pt_BR |
| Abstract | Dengue fever, a public health problem in Brazil, may present severe clinical manifestations as result of an increased vascular permeability and coagulation disorders. T cell activation is a critical event for an effective immune response against infection, including the production of cytokines. We aim to reveal mechanisms that modulate the virus-cell interaction, with an emphasis on cell death. Apoptosis is involved in lymphocyte homeostasis, contributes to the clearance of virus-infected cells but also may play a role in the pathogenesis. Phosphatidylserine exposure on CD8T lymphocytes from dengue patients support early apoptotic processes and loss of genomic integrity, observed by DNA fragmentation in T lymphocytes and indicating late apoptosis. These T cells express activation and cytotoxic phenotypes as revealed by CD29 and CD107a upregulation. Higher frequencies of CD95 were detected in T lymphocytes mainly in those with the cytotoxic profile (CD107a+) and lower levels of anti-apoptotic molecule Bcl-2, suggesting that both CD4+ and CD8+ T cell subsets are more susceptible to apoptosis during acute dengue. The analysis of apoptosis-related protein expression profile showed that not only molecules with pro- but also those with anti-apoptotic functions are overexpressed, indicating that survival mechanisms could be possibly protecting cells against apoptosis caused by viral, immune, oxidative and/or genotoxic stresses. These observations led us to propose that in dengue patients there is an association between T cell susceptibility to apoptosis and the activation state. The mechanisms for understanding the immunopathogenesis during dengue infection are discussed. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | UNIRIO. Hospital Universitário Gafrée Guinle. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Mato Grosso do Sul. Faculdade de Medicina. Departamento de Clínica Médica. Campo Grande, MS, Brasil. | pt_BR |
| Affilliation | BrazildCentro de Referência em Dengue. Faculdade de Medicina. Campos de Goytacases, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Apoptosis | pt_BR |
| Subject | Dengue | pt_BR |
| Subject | Lymphocytes | pt_BR |
| Subject | Activation markers | pt_BR |
| DeCS | Apoptose | pt_BR |
| DeCS | Dengue | pt_BR |
| DeCS | Linfócitos | pt_BR |
