| Author | Moraes, Cristiane | |
| Author | Marinho, Sandra Mara | |
| Author | Nobrega, Antonio Claudio da | |
| Author | Bessa, Bruno de Oliveira | |
| Author | Jacobson, Ludmilla Viana | |
| Author | Pinto, Milena Barcza Stockler | |
| Author | Silva, Wellington Seguins da | |
| Author | Mafra, Denise | |
| Access date | 2015-05-27T13:39:46Z | |
| Available date | 2015-05-27T13:39:46Z | |
| Document date | 2014 | |
| Citation | MORAES, Cristiane et al. Resistance exercise: a strategy to attenuate inflammation and protein-energy wasting in hemodialysis patients?. Int Urol Nephrol., v.46, n.8, p.1655–1662, 2014. | pt_BR |
| ISSN | 1573-2584 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/10531 | |
| Language | eng | pt_BR |
| Publisher | Springer | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Exercício | pt_BR |
| Title | Resistance exercise: a strategy to attenuate inflammation and protein-energy wasting in hemodialysis patients? | pt_BR |
| Type | Article | |
| DOI | 10.1007/s11255-014-0712-3 | pt_BR |
| Abstract | Purpose
Patients undergoing hemodialysis (HD) present persistent inflammation and protein-energy wasting (PEW), which contributes to high rates of mortality. This study aimed to assess the effects of a resistance exercise training program (RETP) on inflammation and PEW in HD patients.
Methods
Thirty-seven patients (56.7 % men, 45.9 ± 14.1 years, 23.5 ± 3.9 kg/m2) performed 6 months of intradialytic RETP. Plasma adhesion molecules levels (ICAM-1 and VCAM-1) were measured using the enzyme immunometric assay, and interleukin-6 (IL-6), C-reactive protein, and tumor necrosis factor-alpha by ELISA. Anthropometric, physical capacity, and PEW (simultaneously presence of: BMI <23 kg/m2, serum albumin <3.8 g/dL, and reduced arm muscle area) were analyzed.
Results
There was a reduction of ICAM-1 [(1,934.1 pg/mL (1,031.8–2,875.0) vs. 1,571.1 pg/mL (447.1–2,985.5), p < 0.05], VCAM-1 [5,259.51 pg/mL (3,967.4–6,682.4) vs. 3,062.11 pg/mL (2,034.0–5,034.4), p < 0.05], and CRP levels (2.3 ± 0.9 to 1.6 ± 0.6 pg/mL, p < 0.001) after 6 months of RETP. Body composition improved, albumin increased (3.7 ± 0.3 to 3.9 ± 0.2, p < 0.05), and the number of patients presenting PEW was decreased (p = 0.005).
Conclusions
Resistance exercise program for 6 months seems to be effective in reducing inflammation and PEW of HD patients. The universal trial number of this study is U1111-1139-1326. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Programa de Pós-Graduação em Ciências Cardiovasculares. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Programa de Pós-Graduação em Ciências Médicas. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Programa de Pós-Graduação em Ciências Cardiovasculares. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Programa de Pós-Graduação em Ciências Médicas. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Departamento de Estatísticas. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Programa de Pós-Graduação em Ciências Cardiovasculares. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Programa de Pós-Graduação em Ciências Médicas. Niterói, RJ, Brasil. | pt_BR |
| Subject | Chronic kidney disease | pt_BR |
| Subject | Hemodialysis | pt_BR |
| Subject | nflammation | pt_BR |
| Subject | Exercise | pt_BR |
| Subject | Cardiovascular disease | pt_BR |
| DeCS | Doenças Cardiovasculares | pt_BR |
| DeCS | Insuficiência Renal Crônica | pt_BR |
| DeCS | Diálise Renal | pt_BR |
| DeCS | Inflamação | pt_BR |
| DeCS | Exercício | pt_BR |
