Author | Vicente, Rafael Perígolo | |
Author | Ritt, Karen | |
Author | Albuquerque, Cassiano Felipe Gonçalves de | |
Author | Faria Neto, Hugo Caire Castro | |
Author | Carvalho, Roberto Paes de | |
Author | Araujo, Elizabeth Giestal de | |
Access date | 2015-05-27T13:39:51Z | |
Available date | 2015-05-27T13:39:51Z | |
Document date | 2014 | pt_BR |
Citation | VICENTE, Rafael Perígolo et al. IL-6, A1 and A2aR: A crosstalk that modulates BDNF and induces neuroprotection. Biochemical and Biophysical Research Communications, v.449,n.4, p.477–482, 2014. | pt_BR |
ISSN | 0006-291X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/10549 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Title | IL-6, A1 and A2aR: A crosstalk that modulates BDNF and induces neuroprotection | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.bbrc.2014.05.036 | pt_BR |
Abstract | Several diseases are related to retinal ganglion cell death, such as glaucoma, diabetes and other retinopathies. Many studies have attempted to identify factors that could increase neuroprotection after axotomy of these cells. Interleukin-6 has been shown to be able to increase the survival and regeneration of retinal ganglion cells (RGC) in mixed culture as well as in vivo. In this work we show that the trophic effect of IL-6 is mediated by adenosine receptor (A2aR) activation and also by the presence of extracellular BDNF. We also show that there is a complex cross-talk between IL-6, BDNF, the Adenosine A1 and A2a receptors that results in neuroprotection of retinal ganglion cells. | pt_BR |
Affilliation | Universidade Federal Fluminense.Instituto de Biologia. Departamento de Neurobiologia. Niterói, Brasil / University of London. Blizard Institute - Queen Mary. London, UK. | pt_BR |
Affilliation | Universidade Federal Fluminense.Instituto de Biologia. Departamento de Neurobiologia. Niterói, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense.Instituto de Biologia. Departamento de Neurobiologia. Niterói, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense.Instituto de Biologia. Departamento de Neurobiologia. Niterói, Brasil | pt_BR |
Subject | Adenosine receptors | pt_BR |
Subject | BDNF | pt_BR |
Subject | Neuronal death | pt_BR |
Subject | Retina | pt_BR |
Subject | Axotomy | pt_BR |
DeCS | Receptores Purinérgicos P1 | pt_BR |
DeCS | Retina | pt_BR |
DeCS | Técnicas de Cultura de Células | pt_BR |
DeCS | Axotomia | pt_BR |