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AutorBittencourt, Achilea Candida Lisboa
AutorMota, Karla Oliveira
AutorOliveira, Rodrigo Ferreira de
AutorVallve, Maria de Lourdes Farre
Fecha de acceso2015-06-08T12:41:07Z
Fecha de disponibilización2015-06-08T12:41:07Z
Fecha de publicación2009
ReferenciaBITTENCOURT, A. C. L. et al. A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report. American Journal of Dermatopathology, v. 31, n. 8, p. 834-837, 2009.pt_BR
ISSN1533-0311
URIhttps://www.arca.fiocruz.br/handle/icict/10649
Idiomaengpt_BR
EditorLippincott Williams & Wilkinspt_BR
Derechos de autoropen accesspt_BR
TítuloA dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report.pt_BR
Tipo del documentoArticlept_BR
Resumen en InglésAdult T-cell leukemia/lymphoma (ATL) is an aggressive type of leukemia/lymphoma associated with the human T-cell lymphotropic virus (HTLV-I). We describe an adult male patient clinically and pathologically diagnosed as mycosis fungoides and treated with chemotherapy after which complete involution of the lesions occurred. The disease relapsed with confluent dyshidrosis-like vesicles on the palmoplantar regions, followed by disseminated vesiculopapules and associated lymphocytosis. A serological test performed at this time revealed HTLV-I infection, and a diagnosis of chronic ATL was made. Monoclonal integration of HTLV-I was detected in peripheral blood mononuclear cells by inverse long polymerase chain reaction. A skin biopsy revealed spongiosis, Pautrier abscesses, and intraepidermal vesicles with atypical lymphocytes and an infiltration of small and atypical CD4 lymphocytes in the superficial dermis. Proliferative index (Ki-67) was 70%. This is the first reported vesicular cutaneous ATL with confirmation of HTLV-I proviral integration. The delay that occurred in diagnosing ATL was due to the fact that mycosis fungoides and ATL may present the same clinical, histopathological, and immunohistochemical features.pt_BR
AfiliaciónUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia, Medicina Interna. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasilpt_BR
AfiliaciónUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia, Medicina Interna. Salvador, BA, Brasilpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasilpt_BR
Palavras clave en InglêsAdult T-cell leukemia/lymphoma,pt_BR
Palavras clave en InglêsMycosis fungoidespt_BR
Palavras clave en InglêsHTLV-I infectionpt_BR
DeCSEczema Disidrótico/patologiapt_BR
DeCSInfecções por HTLV-I/patologiapt_BR
DeCSLeucemia-Linfoma de Células T do Adulto/patologiapt_BR
DeCSMicose Fungoide/patologiapt_BR
DeCSNeoplasias Cutâneas/patologiapt_BR
DeCSAdultopt_BR
DeCSProtocolos de Quimioterapia Combinada Antineoplásica/uso terapêuticopt_BR
DeCSCiclofosfamidapt_BR
DeCSDiabetes Mellituspt_BR
DeCSDiagnóstico Diferencialpt_BR
DeCSDoxorrubicinapt_BR
DeCSEczema Disidrótico/virologiapt_BR
DeCSInfecções por HTLV-I/complicaçõespt_BR
DeCSHumanospt_BR
DeCSImuno-Histoquímicapt_BR
DeCSLeucemia-Linfoma de Células T do Adulto/quimioterapiapt_BR
DeCSMicose Fungoide/quimioterapiapt_BR
DeCSNeoplasias Cutâneas/quimioterapiapt_BR


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