| Author | Cruz, Daniella Arêas Mendes da | |
| Author | Brignier, Anne Colette | |
| Author | Asnafi, Vahid | |
| Author | Beleydier, Frederic | |
| Author | Messias, Carolina Valença | |
| Author | Lepelletier, Yves | |
| Author | Bedjaoui, Nawel | |
| Author | Renand, Amedée | |
| Author | Smaniotto, Salete | |
| Author | Canloni, Danielle | |
| Author | Milpied, Pierre | |
| Author | Balabanian, Karl | |
| Author | Bousso, Phillippe | |
| Author | Leprétre, Stéphane | |
| Author | Bertrand, Yves | |
| Author | Dombret, Hervé | |
| Author | Ifrah, Norbert | |
| Author | Dardenne, Mireille | |
| Author | Macintyre, Elizabeth | |
| Author | Savino, Wilson | |
| Author | Hermine, Olivier | |
| Access date | 2015-06-08T14:01:46Z | |
| Available date | 2015-06-08T14:01:46Z | |
| Document date | 2014 | |
| Citation | CRUZ, Daniella Arêas Mendes da; et al. Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors. Plos One, v.9, n.7, 7p, 2014. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/10675 | |
| Language | eng | pt_BR |
| Publisher | Plos One | pt_BR |
| Rights | open access | |
| Title | Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0103405 | pt_BR |
| Abstract | Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the
developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we
describe the expression and role of semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) in human T cell
precursors. NRP2 and SEMA3F are expressed in the human thymus, in both lymphoid and non-lymphoid compartments.
SEMA3F have a repulsive effect on thymocyte migration and inhibited CXCL12- and sphingosine-1-phosphate (S1P)-induced
thymocyte migration by inhibiting cytoskeleton reorganization prior to stimuli. Moreover, NRP2 and SEMA3F are expressed
in human T-cell acute lymphoblastic leukemia/lymphoma primary cells. In these tumor cells, SEMA3F also blocks their
migration induced by CXCL12 and S1P. Our data show that SEMA3F and NRP2 are further regulators of human thymocyte
migration in physiological and pathological conditions. | pt_BR |
| Affilliation | CNRS UMR8147, Paris Descartes University, Paris, France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | CNRS UMR8147, Paris Descartes University, Paris, France / Assistance Publique-Hôpitaux de Paris (AP-HP). Necker Children’s Hospital. Department of Clinical Hematology. Paris, France. | pt_BR |
| Affilliation | Necker Children’s Hospital. Laboratory of Oncohematology, AP-HP. Paris, France. | pt_BR |
| Affilliation | Necker Children’s Hospital. Laboratory of Oncohematology, AP-HP. Paris, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | CNRS UMR8147, Paris Descartes University, Paris, France / Imagine Institute. INSERM U1163, CNRS ERL 8254, Laboratory of cellular and molecular basis of hematological disorders and their therapeutic implications. Paris, France. | pt_BR |
| Affilliation | Necker Children’s Hospital. Laboratory of Oncohematology, AP-HP. Paris, France. | pt_BR |
| Affilliation | CNRS UMR8147, Paris Descartes University, Paris, France. | pt_BR |
| Affilliation | Universidade Federal de Alagoas. Departamento de Morfologia. Macei[o, AL, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Alagoas. Departamento de Morfologia. Macei[o, AL, Brasil /Necker Children’s Hospital. Laboratory of Oncohematology, AP-HP. Paris, France. | pt_BR |
| Affilliation | CNRS UMR8147, Paris Descartes University, Paris, France. | pt_BR |
| Affilliation | INSERM U819 – Pasteur Institute, Paris, France. | pt_BR |
| Affilliation | INSERM U668 – Pasteur Institute. Paris, France. | pt_BR |
| Affilliation | Centre Henri Becquerel. Department of Hematology. Rouen, France. | pt_BR |
| Affilliation | Hôpital Debrousse. Service of Pediatric Hematology. Lyon, France. | pt_BR |
| Affilliation | University Paris 7, Hôpital Saint-Louis, AP-HP. Institut Universitaire d’He´matologie EA3518. Paris, France. | pt_BR |
| Affilliation | Pôle de Recherche et d’Enseignement Supérieur l’Université Nantes Angers Le Mans. Centre Hospitalier Universitaire Angers. Service des Maladies du Sang and INSERM U892. Angers, France | pt_BR |
| Affilliation | CNRS UMR8147, Paris Descartes University, Paris, France. | pt_BR |
| Affilliation | Necker Children’s Hospital. Laboratory of Oncohematology, AP-HP. Paris, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | CNRS UMR8147, Paris Descartes University, Paris, France / Necker Children’s Hospital. Laboratory of Oncohematology, AP-HP. Paris, France / | pt_BR |
| Affilliation | Imagine Institute. INSERM U1163, CNRS ERL 8254, Laboratory of cellular and molecular basis of hematological disorders and their therapeutic implications. Paris, France. | pt_BR |
| Subject | Thymus | pt_BR |
| Subject | Neuropillins | pt_BR |
| Subject | Semaphorins | pt_BR |
| Subject | Lymphoma | pt_BR |
| Subject | Leukemia | pt_BR |
| Subject | Human T-Cell Precursors | pt_BR |
| DeCS | Neuropilinas | pt_BR |
| DeCS | Semaforinas | pt_BR |
| DeCS | Leucemia | pt_BR |
| DeCS | Linfoma | pt_BR |
