| Author | Maselli, Luciana M. F | |
| Author | Levy, Debora | |
| Author | Laporta, Gabriel Z | |
| Author | Monteiro, Aline M | |
| Author | Fukuya, Linah A | |
| Author | Cruz, Maria F. Ferreira da | |
| Author | Daniel-Ribeiro, Cláudio Tadeu | |
| Author | Llacer, Pedro E. Dorlhiac | |
| Author | Sallum, Maria Anice M | |
| Author | Bydlowski, Sérgio P | |
| Access date | 2015-06-08T14:01:50Z | |
| Available date | 2015-06-08T14:01:50Z | |
| Document date | 2014 | |
| Citation | MASELLI, Luciana M. F. et al. Detection of Plasmodium falciparum and Plasmodium vivax subclinical infection in non-endemic region: implications for blood transfusion and malaria epidemiology. Malaria Journal, v.13:224, 9p, 2914. | pt_BR |
| ISSN | 1475-2875 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/10691 | |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | |
| Title | Detection of Plasmodium falciparum and Plasmodium vivax subclinical infection in non-endemic region: implications for blood transfusion and malaria epidemiology | pt_BR |
| Type | Article | |
| DOI | 10.1186/1475-2875-13-224 | pt_BR |
| Abstract | Background: In Brazil, malaria is endemic in the Amazon River basin and non-endemic in the extra-Amazon region,
which includes areas of São Paulo state. In this state, a number of autochthonous cases of malaria occur annually,
and the prevalence of subclinical infection is unknown. Asymptomatic infections may remain undetected, maintaining
transmission of the pathogen, including by blood transfusion. In these report it has been described subclinical
Plasmodium infection in blood donors from a blood transfusion centre in São Paulo, Brazil.
Methods: In this cross-sectional study, representative samples of blood were obtained from 1,108 healthy blood
donors at the Fundação Pró-Sangue Hemocentro de São Paulo, the main blood transfusion centre in São Paulo.
Malaria exposure was defined by the home region (exposed: forest region; non-exposed: non-forest region).
Real-time PCR was used to detect Plasmodium falciparum and Plasmodium vivax. Subclinical malaria cases were
geo-referenced.
Results: Eighty-four (7.41%) blood donors tested positive for Plasmodium; 57 of these were infected by P. falciparum,
25 by P. vivax, and 2 by both. The prevalence of P. falciparum and P. vivax was 5.14 and 2.26, respectively. The overall
prevalence ratio (PR) was 3.23 (95% confidence interval (CI) 2.03, 5.13); P. falciparum PR was 16.11 (95% CI 5.87, 44.21) and
P. vivax PR was 0.47 (95% CI 0.2, 1.12). Plasmodium falciparum subclinical malaria infection in the Atlantic Forest domain
was present in the mountain regions while P. vivax infection was observed in cities from forest-surrounded areas.
Conclusions: The presence of Plasmodium in healthy blood donors from a region known as non-endemic, which is
important in the context of transfusion biosafety, was described. Infected recipients may become asymptomatic carriers
and a reservoir for parasites, maintaining their transmission. Furthermore, P. falciparum PR was positively associated with
the forest environment, and P. vivax was associated with forest fragmentation. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. Laboratório de Genética e Hematologia Molecular. São Paulo, SP, Brasil / Fundação Pró-Sangue Hemocentro de São Paulo. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. Laboratório de Genética e Hematologia Molecular. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Epidemiologia. Faculdade de Medicina. Laboratório de Informática Médica. São Paulo, SP, Brasil / | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. Hospital das Clínicas. Divisão de Hematologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. Hospital das Clínicas. Divisão de Hematologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. Hospital das Clínicas. Divisão de Hematologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | niversidade de São Paulo. Faculdade de Saúde Pública. Departamento de Epidemiologia. São Paulo, SP, brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. Laboratório de Genética e Hematologia Molecular. São Paulo, SP, Brasil | pt_BR |
| Subject | Plasmodium falciparum | pt_BR |
| Subject | Plasmodium falciparum | pt_BR |
| Subject | Subclinical infection | pt_BR |
| Subject | Blood center | pt_BR |
| Subject | Transfusion | pt_BR |
| Subject | Prevalence ratio | pt_BR |
| Subject | Dynamics of malaria transmission | pt_BR |
| DeCS | Plasmodium falciparum | pt_BR |
| DeCS | Malária | pt_BR |
| DeCS | Plasmodium falciparum | pt_BR |
| DeCS | Transfusão de Sangue | pt_BR |
| DeCS | Razão de Prevalências | pt_BR |
