| Author | Oliveira, Maria de Fátima Paim de | |
| Author | Vieira, Maria das Graças | |
| Author | Primo, Janeusa Rita Leite | |
| Author | Siqueira, Isadora Cerqueira de | |
| Author | Carvalho Filho, Edgar Marcelino | |
| Author | Vallve, Maria de Lourdes Farre | |
| Author | Fatal, Priscila Lima | |
| Author | Bittencourt, Achilea Candida Lisboa | |
| Access date | 2015-06-10T17:55:42Z | |
| Available date | 2015-06-10T17:55:42Z | |
| Document date | 2010 | |
| Citation | OLIVEIRA, M. F. P. et al. Flower cellsin patient swith infective dermatitis associated with HTLV-1. Journal of Clinical Virology, v. 48, n. 4, p. 288-290, 2010 . | pt_BR |
| ISSN | 1386-6532 | |
| URI | https://www.arca.fiocruz.br/handle/icict/10781 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Title | Flower cellsin patient swith infective dermatitis associated with HTLV-1 | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.jcv.2010.05.005 | |
| Abstract | BACKGROUND: Infective dermatitis associated with HTLV-1 (IDH) is a severe childhood form of eczema that may progress to adult T-cell leukemia/lymphoma (ATL). OBJECTIVE: In this study, the presence of clinical and laboratory parameters suggestive of ATL was evaluated in a cohort of 30 patients with IDH. STUDY DESIGN: Over a period of 33 months, the patients were submitted to three-monthly clinical evaluations, routine laboratory exams, full blood count and blood smears, and to six-monthly blood sampling for HTLV-1 proviral load determination. HTLV-1 proviral load was quantified using real-time TaqMan PCR assay. RESULTS: Abnormal cells (Ably) were found in the peripheral blood smears of nine patients (30%), flower cells being detected in five of these cases (16.6%). The presence of Ably and flower cells was not associated with a higher proviral load in those patients. CONCLUSIONS: This is the first report on the presence of flower cells in HTLV-1-infected children and adolescents. Furthermore, these cells have not previously been reported in IDH patients. The cases with flower cells probably represent precursory ATL cases, these patients being at a greater risk of developing ATL. | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Dermatology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Pathology. Salvador, BA, BrasilFederal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Pathology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Internal Medicine. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Laboratory ofImmunology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Laboratory ofImmunology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Dermatology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Pathology. Salvador, BA, BrasilFederal University of Bahia. Professor Edgar Santos Teaching Hospital. Department of Pathology. Salvador, BA, Brasil | pt_BR |
| Subject | HTLV-1 infection | pt_BR |
| Subject | Infective dermatitisassociatedwithHTLV-1 | pt_BR |
| Subject | Adult T-cellleukemia/lymphoma | pt_BR |
| Subject | Flower cells | pt_BR |
| Subject | Skin diseasescausedbyHTLV-1 | pt_BR |
| DeCS | Dermatite/virologia | pt_BR |
| DeCS | Infecções por HTLV-I/diagnóstico | pt_BR |
| DeCS | Vírus 1 Linfotrópico T Humano/isolamento & purificação | pt_BR |
| DeCS | Linfócitos/patologia | pt_BR |
| DeCS | Dermatopatias Virais/diagnóstico | pt_BR |
| DeCS | Adolescente | pt_BR |
| DeCS | Sangue/virologia | pt_BR |
| DeCS | Criança | pt_BR |
| DeCS | Pré-Escolar | pt_BR |
| DeCS | Sangue/virologia | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Infecções por HTLV-I/virologia | pt_BR |
| DeCS | Vírus 1 Linfotrópico T Humano/genética | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Reação em Cadeia da Polimerase | pt_BR |
| DeCS | Provirus/genética | pt_BR |
| DeCS | Provirus/isolamento & purificação | pt_BR |
