| Author | Xavier-Elsas, Pedro Paulo | |
| Author | Santos-Maximiano, E. | |
| Author | Queto, T. | |
| Author | Mendonça-Sales, S. | |
| Author | Joseph, D. | |
| Author | Gaspar-Elsas, M. I. C. | |
| Author | Vargaftig, B. B. | |
| Access date | 2015-06-11T17:09:12Z | |
| Available date | 2015-06-11T17:09:12Z | |
| Document date | 2007 | |
| Citation | XAVIER-ELSAS, P. et al. Ectopic lung transplantation induces the accumulation of eosinophil progenitors in the recipients’ lungs through an allergen- and interleukin-5-dependent mechanism. Clinical and Experimental Allergy, Oxford, v. 37, n. 1, p. 29–38, 2007. | pt_BR |
| ISSN | 0954-7894 | |
| URI | https://www.arca.fiocruz.br/handle/icict/10795 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Title | Ectopic lung transplantation induces the accumulation of eosinophil progenitors in the recipients’ lungs through an allergen- and interleukin-5-dependent mechanism | pt_BR |
| Type | Article | |
| DOI | 10.1111/j.1365-2222.2006.02623.x | |
| Abstract | Background Airway challenge of ovalbumin-sensitized mice induces intrapulmonary
accumulation of eosinophil progenitors.
Objective To evaluate whether allergen-challenged lungs release factors promoting
intrapulmonary accumulation of haemopoietic cells, and define the role of allergic lung
injury, we developed a transplantation model.
MethodsLung tissue from allergen-challenged, sensitized donors was ectopically grafted in
syngeneic recipients, and haemopoietic progenitors inside the lungs of the recipients were
quantified.
ResultsIn BALB/c mice, accumulation of progenitors occurred only when: (a) donors were
sensitized and airway challenged with homologous allergen; (b) and recipients were
sensitized. Grafts from the appropriate donors released biologically active IL-5, which was
effective in sensitized recipients. The effect of the appropriate donor–recipient combination
was prevented by neutralizing anti-IL-5 antibody. Grafts from unchallenged, sensitized
donors synergized with recombinant IL-5 in sensitized recipients. Unlike BALB/c, grafts from
naı¨ve IL-5 transgenic CBA/Ca mice (whose lungs contained a large number of progenitors,
independently of sensitization and challenge) were effective in non-transgenic, ovalbumin-sensitized recipients.
ConclusionThis shows that: (a) intrapulmonary accumulation of progenitors is independent
of immunological injury; (b) grafts systemically release IL-5, which is required for progenitor
accumulation in the recipients’ lungs; (c) and sensitization is required for full responsiveness
to IL-5 and for generation of lung-derived signals that synergize with IL-5. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Puericultura e Pediatria Martagão Gesteira. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Laboratório de Fisiopatologia Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Laboratório de Fisiopatologia Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Laboratório de Fisiopatologia Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Unité Associée Institut Pasteur. Unité de Pharmacologie Cellulaire. Paris, France | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Laboratório de Fisiopatologia Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Unité Associée Institut Pasteur. Unité de Pharmacologie Cellulaire. Paris, France / Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Farmacologia. São Paulo, SP, Brasil. | pt_BR |
| Subject | Eosinophils | pt_BR |
| Subject | Haematopoiesis | pt_BR |
| Subject | Lung | pt_BR |
| Subject | Transplantation | pt_BR |
| DeCS | Eosinófilos | pt_BR |
| DeCS | Hematopoese | pt_BR |
| DeCS | Pulmão | pt_BR |
| DeCS | Transplante | pt_BR |
