| Author | Gurgel, Clarissa Araújo Silva | |
| Author | Ramos, Eduardo Antônio Gonçalves | |
| Author | Melo, Leonardo Araújo | |
| Author | Schlaepf, Caroline Brandi | |
| Author | Souza, Renata Oliveira de | |
| Author | Oliveira, Márcio Campos | |
| Author | Santos, Jean Nunes dos | |
| Access date | 2015-06-16T19:22:59Z | |
| Available date | 2015-06-16T19:22:59Z | |
| Document date | 2009 | |
| Citation | GURGEL, C. A. S. et al. Immunolocalisation of laminin-1 in keratocystic odontogenic tumors. Acta Histochemica, v. 112, n. 6, p. 624-629, 2010. | pt_BR |
| ISSN | 0065-1281 | |
| URI | https://www.arca.fiocruz.br/handle/icict/10856 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Title | Immunolocalisation of laminin-1 in keratocystic odontogenic tumors. | pt_BR |
| Type | Article | pt_BR |
| Abstract | Keratocystic odontogenic tumors (KOTs) are distinct odontogenic lesions frequently affecting the jawbones. They may be associated with nevoid basal cell carcinoma syndrome (NBCCS), and may exhibit disorders involving the extracellular matrix. The aim of this study was to investigate the immunolocalisation of laminin-1 in 20 cases of KOTs in order to contribute to the characterization of this protein, which is little studied in odontogenic tumors. Our results showed laminin-1 in all 20 KOTs studied; its labelling intensity was weak in three cases (15%), moderate in five (25%) and strong in 12 cases (60%). Laminin-1 immunolocalisation was predominantly continuous in 18 (90%) KOTs, including areas of acanthosis, subepithelial split and epithelial buds. Weak immunolabelling was observed in regions exhibiting an inflammatory process, especially in the case of intense inflammation. These findings suggest that laminin-1 does not participate in biological processes such as cystic epithelium-cystic wall separation or the formation of epithelial islands in KOTs. Furthermore, the discontinuous and weak labelling of this protein in the basement membrane of these tumors is probably a consequence of the inflammatory process in the tumor stroma | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Salvador, BA, Brasil | pt_BR |
| Affilliation | University of Feira de Santana. School of Dentistry. Laboratory of Oral Surgical Pathology. Feira de Santana, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil | pt_BR |
| Subject | Keratocysticodontogenic tumors | pt_BR |
| Subject | Laminin-1 | pt_BR |
| Subject | Immunohistochemistry | pt_BR |
| DeCS | Neoplasias Maxilomandibulares/metabolismo | pt_BR |
| DeCS | Neoplasias Maxilomandibulares/patologia | pt_BR |
| DeCS | Laminina/análise | pt_BR |
| DeCS | Tumores Odontogênicos/metabolismo | pt_BR |
| DeCS | Tumores Odontogênicos/patologia | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Imuno-Histoquímica | pt_BR |
| DeCS | Neoplasias Maxilomandibulares/imunologia | pt_BR |
| DeCS | Laminina/imunologia | pt_BR |
| DeCS | Tumores Odontogênicos/imunologia | pt_BR |
