| Autor | Kojic, Erna Milunka | |
| Autor | Kang, Minhee | |
| Autor | Cespedes, Michelle S. | |
| Autor | Umbleja, Triin | |
| Autor | Godfrey, Catherine | |
| Autor | Allen, Reena T. | |
| Autor | Firnhaber, Cynthia | |
| Autor | Grinsztejn, Beatriz | |
| Autor | Palefsky, Joel M. | |
| Autor | Cyriaque, Jennifer Y. Webster | |
| Autor | Saah, Alfred | |
| Autor | Aberg, Judith A. | |
| Autor | Cu-Uvin, Susan | |
| Data de acesso | 2015-06-30T16:05:15Z | |
| Data de disponibilização | 2015-06-30T16:05:15Z | |
| Data do publicação | 2014 | |
| Citação | KOJIC, Erna Milunka et al. Immunogenicity and safety of the quadrivalent human papillomavirus vaccine in HIV-1– infected women. Clinical Infectious Diseases, v.59, n.1, p.127-135, 2014. | pt_BR |
| ISSN | 1058-4838 | |
| URI | https://www.arca.fiocruz.br/handle/icict/11016 | |
| Idioma | eng | pt_BR |
| Editor | Oxford University Press | pt_BR |
| Direito Autoral | restricted access | pt_BR |
| Título | Immunogenicity and safety of the quadrivalent human papillomavirus vaccine in HIV-1– infected women | pt_BR |
| Tipo do documento | Article | |
| DOI | 10.1093/cid/ciu238 | |
| Resumo em Inglês | Background. Women infected with human immunodeficiency virus (HIV) are disproportionately affected by human papillomavirus (HPV)–related anogenital disease, particularly with increased immunosuppression. AIDS Clinical Trials Group protocol A5240 was a trial of 319 HIV-infected women in the United States, Brazil, and South Africa to determine immunogenicity and safety of the quadrivalent HPV vaccine in 3 strata based on screening CD4 count: >350 (stratum A), 201–350 (stratum B), and ≤200 cells/µL (stratum C).
Methods. Safety and serostatus of HPV types 6, 11, 16, and 18 were examined. HPV serological testing was performed using competitive Luminex immunoassay (HPV-4 cLIA). HPV type-specific seroconversion analysis was done for participants who were seronegative for the given type at baseline.
Results. Median age of patients was 36 years; 11% were white, 56% black, and 31% Hispanic. Median CD4 count was 310 cells/µL, and 40% had undetectable HIV-1 load. No safety issues were identified. Seroconversion proportions among women at week 28 for HPV types 6, 11,16, and 18 were 96%, 98%, 99%, and 91%, respectively, for stratum A; 100%, 98%, 98%, and 85%, respectively, for stratum B, and 84%, 92%, 93%, and 75%, respectively, for stratum C.
Conclusions. The quadrivalent HPV vaccine targeted at types 6, 11, 16, and 18 was safe and immunogenic in HIV-infected women aged 13–45 years. Women with HIV RNA load >10 000 copies/mL and/or CD4 count <200 cells/µL had lower rates of seroconversion rates. | pt_BR |
| Afiliação | Brown University. Department of Infectious Disease. Providence, RI, United States of America | pt_BR |
| Afiliação | Harvard School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, United States of America | pt_BR |
| Afiliação | Icahn School of Medicine at Mount Sinai. Division of Infectious Diseases. New York City, NY, United Sates of America | pt_BR |
| Afiliação | Harvard School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, United States of America | pt_BR |
| Afiliação | National Institute of Allergy and Infectious Diseases. National Institutes of Health. HIV Research Branch. Therapeutics Research Program. Division of AIDS. Bethesda, MD, United States of America | pt_BR |
| Afiliação | AIDS Clinical Trials Group Network Coordinating Center. Silver Spring, MD, United States of America | pt_BR |
| Afiliação | University of the Witwatersrand. Department of Internal Medicine. Faculty of Health Sciences. Clinical HIV Research Unit. Johannesburg, South Africa | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Afiliação | University of California. Department of Medicine. San Francisco, CA, United States of America | pt_BR |
| Afiliação | University of North Carolina. Oral HIV/AIDS Research Alliance. Virology, Microbiology and Immunology, Dental Ecology. Chapel Hill, NC, United States of America | pt_BR |
| Afiliação | Merck Research Labs. North Wales, PA, United States of America | pt_BR |
| Afiliação | Icahn School of Medicine at Mount Sinai. Division of Infectious Diseases. New York City, NY, United Sates of America | pt_BR |
| Afiliação | Brown University. Department of Infectious Disease. Providence, RI, United States of America | pt_BR |
| Palavras-chave em inglês | Papillomavirus Vaccines | pt_BR |
| Palavras-chave em inglês | HIV | pt_BR |
| Palavras-chave em inglês | Immunosuppression | pt_BR |
| Palavras-chave em inglês | Statistical Analysis | pt_BR |
| DeCS | Vacinas contra Papillomavirus | pt_BR |
| DeCS | HIV | pt_BR |
| DeCS | Imunossupressão | pt_BR |
| DeCS | Análise Estatística | pt_BR |
| e-ISSN | 1537-6591 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
