| Author | Bavinton, Benjamin R. | |
| Author | Jin, Fengyi | |
| Author | Prestage, Garrett | |
| Author | Zablotska, Iryna | |
| Author | Koelsch, Kersten K. | |
| Author | Phanuphak, Nittaya | |
| Author | Grinsztejn, Beatriz | |
| Author | Cooper, David A. | |
| Author | Fairley, Christopher | |
| Author | Kelleher, Anthony | |
| Author | Triffitt, Kathy | |
| Author | Grulich, Andrew E. | |
| Access date | 2015-06-30T18:36:32Z | |
| Available date | 2015-06-30T18:36:32Z | |
| Document date | 2014 | |
| Citation | BAVINTON, Benjamin R. et al. The opposites attract study of viral load, HIV treatment and HIV transmission in serodiscordant homosexual male couples: design and methods. BMC Infectious Diseases, v.14, n.917, p.1-8, 2014. | pt_BR |
| ISSN | 1471-2334 | |
| URI | https://www.arca.fiocruz.br/handle/icict/11030 | |
| Sponsorship | National Health and Medical Research Council Project | pt_BR |
| Language | eng | pt_BR |
| Publisher | BioMed Central | pt_BR |
| Rights | open access | pt_BR |
| Title | The opposites attract study of viral load, hiv treatment and HIV transmission in serodiscordant homosexual male couples: design and methods | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1186/1471-2458-14-917 | |
| Abstract | Background: Studies in heterosexual HIV serodiscordant couples have provided critical evidence on the role of HIV
treatments and undetectable viral load in reducing the risk of HIV transmission. There is very limited data on the
risk of transmission from anal sex in homosexual male serodiscordant couples.
Methods/Design: The Opposites Attract Study is an observational prospective longitudinal cohort study of male
homosexual serodiscordant partnerships running from 2012 to 2015 and conducted in clinics throughout Australia,
Brazil and Thailand. Couples attend two or more clinic visits per year. The HIV-positive partner’s viral load is tested
and the HIV-negative partner is tested for HIV antibodies at every clinic visit. Results from any tests for sexually
transmitted infections are also collected. Detailed behavioural questionnaires are completed by both partners at the
time of each visit. The primary research question is whether HIV incidence is lower in those couples where the
HIV-positive partner is receiving HIV treatment compared to couples where he is not receiving treatment. A
voluntary semen sub-study will examine semen plasma viral load in a subsample of HIV-positive partners in Sydney,
Rio de Janeiro and Bangkok. In cases of seroconversion of the initially HIV-negative partner, phylogenetic analysis
will be conducted at the end of the study on virus from stored blood samples from both partners to determine if
the infection came from the HIV-positive study partner. Men in new serodiscordant relationships will specifically be
targeted for recruitment.
Discussion: This study will provide critical data on the reduction in HIV transmission risk associated with being on
HIV treatment in homosexual male serodiscordant couples in different regions of the world. Data from men in new
relationships will be particularly valuable given that the highest transmission risk is in the first year of serodiscordant
relationships. Furthermore, the detailed behavioural and attitudinal data from the participant questionnaires will
allow exploration of many contextual factors associated with HIV risk, condom use and the negotiation of sexual
practice within couples. | pt_BR |
| Affilliation | University of New South Wales. The Kirby Institute. Sydney, Australia | pt_BR |
| Affilliation | University of New South Wales. The Kirby Institute. Sydney, Australia | pt_BR |
| Affilliation | University of New South Wales. The Kirby Institute. Sydney, Australia / La Trobe University. Australian Research Centre in Sex. Health and Society. Melbourne, Australia | pt_BR |
| Affilliation | University of New South Wales. The Kirby Institute. Sydney, Australia | pt_BR |
| Affilliation | University of New South Wales. The Kirby Institute. Sydney, Australia / St. Vincent’s Hospital. Sydney, Australia | pt_BR |
| Affilliation | Thai Red Cross AIDS Research Centre. Bangkok, Thailand | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | University of New South Wales. The Kirby Institute. Sydney, Australia / St. Vincent’s Hospital. Sydney, Australia | pt_BR |
| Affilliation | Melbourne Sexual Health Centre. Victoria, Australia / Monash University. Victoria, Australia | pt_BR |
| Affilliation | University of New South Wales. The Kirby Institute. Sydney, Australia / St. Vincent’s Hospital. Sydney, Australia / St. Vincent’s Hospital. St. Vincent’s Centre for Applied Medical Research. Darlinghurst, Australia | pt_BR |
| Affilliation | University of New South Wales. The Kirby Institute. Sydney, Australia | pt_BR |
| Affilliation | University of New South Wales. The Kirby Institute. Sydney, Australia | pt_BR |
| Subject | HIV | pt_BR |
| Subject | Homosexuality | pt_BR |
| Subject | Antiretroviral Therapy, Highly Active | pt_BR |
| Subject | Statistical Analysis | pt_BR |
| DeCS | HIV | pt_BR |
| DeCS | Homossexualidade | pt_BR |
| DeCS | Terapia Antirretroviral de Alta Atividade | pt_BR |
| DeCS | Análise Estatística | pt_BR |
| e-ISSN | 1471-2334 | |
