| Author | Calvet, Guilherme Amaral | |
| Author | Velasque, Luciane de Souza | |
| Author | Luz, Paula Mendes | |
| Author | Cardoso, Sandra Wagner | |
| Author | Pedrosa, Monica Derrico | |
| Author | Moreira, Ronaldo Ismério | |
| Author | Andrade, Angela Cristina Vasconcelos de | |
| Author | Cytryn, Andrea | |
| Author | Pires, Elaine | |
| Author | Veloso,Valdiléa G. | |
| Author | Grinsztejn, Beatriz | |
| Author | Friedman, Ruth Khalili | |
| Access date | 2015-07-06T13:06:45Z | |
| Available date | 2015-07-06T13:06:45Z | |
| Document date | 2014 | |
| Citation | CALVET, Guilherme Amaral et al. Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil. Plos One, v. 9, n. 2, p. 1-6, 2014. | pt_BR |
| ISSN | 1932-6203 | |
| URI | https://www.arca.fiocruz.br/handle/icict/11092 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Title | Absence of effect of menopause status at initiation of first-line antiretroviral therapy on immunologic or virologic responses: a cohort study from Rio de Janeiro, Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pone.0089299 | |
| Abstract | Objective: To compare the effectiveness of first-line combination antiretroviral therapy (cART) between premenopausal and
postmenopausal women. Methods: ART-naı¨ve women initiating cART between January 2000/June 2010 at the Instituto de Pesquisa Clı´nica Evandro Chagas Cohort were studied. Women were defined as postmenopausal after 12 consecutive months of amenorrhea. CD4
cell counts and HIV-1 RNA viral load (VL) measurements were compared between pre- and postmenopausal at 6, 12 and 24 months after cART initiation. Women who modified/discontinued a drug class or died due to an AIDS defining illness were classified as ART-failures. Variables were compared using Wilcoxon test, x2 or Fisher’s exact test. The odds of cART
effectiveness (VL,400 copies/mL and/or no need to change cART) were compared using logistic regression. Linear model was used to access relationship between CD4 change and menopause. Results: Among 383 women, 328 (85%) were premenopausal and 55 (15%) postmenopausal. Median pre cART CD4 counts were 231 and 208 cells/mm3 (p=0.14) in pre- and postmenopausal women, respectively. No difference in the median pre cART VL was found (both 4.8 copies/mL). Median CD4 changes were similar at 6 and 12 months. At 24 months after cART initiation, CD4 changes among postmenopausal women were significantly lower among premenopausal women (p=0.01). When the analysis was restricted to women with VL,400 copies/mL, no statistical difference was observed. Overall, 63.7% achieved cART effectiveness at 24 months without differences between groups at 6, 12 and 24 months. Conclusion: Menopause status at the time of first-line cART initiation does not impact CD4 cell changes at 24 months among women with a virologic response. No relationship between menopause status and virologic response was observed. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Matemática e Estatística. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil | pt_BR |
| Subject | Antiretroviral Therapy | pt_BR |
| Subject | Premenopause | pt_BR |
| Subject | Postmenopause | pt_BR |
| Subject | HIV | pt_BR |
| Subject | Menopause | pt_BR |
| Subject | Anti-Retroviral Agents | pt_BR |
| Subject | Cohort Studies | pt_BR |
| Subject | Brazil/ethnology | pt_BR |
| Subject | Highly Active | pt_BR |
| DeCS | Terapia Antirretroviral de Alta Atividade | pt_BR |
| DeCS | Pré-Menopausa | pt_BR |
| DeCS | Pós-Menopausa | pt_BR |
| DeCS | HIV | pt_BR |
| DeCS | Menopausa | pt_BR |
| DeCS | Antirretrovirais | pt_BR |
| DeCS | Estudos de Coortes | pt_BR |
| DeCS | Brasil/etnologia | pt_BR |
| e-ISSN | 1932-6203 | |
