| Author | Coriolano, Marília Cavalcanti | |
| Author | Melo, Cristiane Moutinho Lagos de | |
| Author | Silva, Flávio de Oliveira | |
| Author | Schirato, Giuliana Viegas | |
| Author | Porto, Camila Souza | |
| Author | Santos, Paulo Jorge Parreira dos | |
| Author | Correia, Maria Tereza dos Santos | |
| Author | Porto, Ana Lúcia Figueiredo | |
| Author | Leão, Ana Maria dos Anjos Carneiro | |
| Author | Coelho, Luana Cassandra Breitenbach Barroso | |
| Access date | 2015-07-08T12:31:21Z | |
| Available date | 2015-07-08T12:31:21Z | |
| Document date | 2014 | |
| Citation | CORIOLANO, Marília Cavalcanti et al. Parkia pendula Seed Lectin: Potential Use to Treat Cutaneous Wounds in Healthy and Immunocompromised Mice. Appl Biochem Biotechnol, v.172, p.2682–2693, 2014. | pt_BR |
| ISSN | 0273-2289 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11154 | |
| Language | eng | pt_BR |
| Publisher | Springer | pt_BR |
| Rights | restricted access | |
| Title | Parkia pendula Seed Lectin: Potential Use to Treat Cutaneous Wounds in Healthy and Immunocompromised Mice | pt_BR |
| Type | Article | |
| DOI | 10.1007/s12010-013-0692-2 | pt_BR |
| Abstract | Parkia pendula seed lectin was used to treat cutaneous wounds of normal and
immunocompromised mice, inducing cicatrization. Methotrexate (0.8 mg/kg/week) was used
as immunosuppressive drug. Wounds were produced in the dorsal region (1 cm2
) of female
albino Swiss mice (Mus musculus), health and immunocompromised. Wounds were daily
topically treated with 100 μL of the following solutions: (1) control (NaCl 0.15 M), (2) control
Im (0.15 M NaCl), (3) P. pendula seed lectin (100 μg/mL), and (4) P. pendula seed lectin Im
(100 μg/mL). Clinical evaluation was performed during 12 days. Biopsies for histopathology
analysis and microbiological examinations were carried out in the second, seventh, and 12th
days. The presence of edema and hyperemia was observed in all groups during inflammatory
period. The first crust was detected from the second day, only in the groups treated with
P. pendula seed lectin. Microbiological analysis of wounds from day 0 to day 2 did not show
bacterium at P. pendula seed lectin group; however, Staphylococcus sp. was detected every
day in the other groups. The lectin markedly induced a total wound closing at P. pendula seed | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Bioquímica. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães—CPqAM. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami (LIKA). Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães—CPqAM. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami (LIKA). Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Zoologia. Recife, PE. Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Bioquímica. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami (LIKA). Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Departamento de Morfologia e Fisiologia Animal. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Bioquímica. Recife, PE, Brasil. | pt_BR |
| Subject | Parkia pendula | pt_BR |
| Subject | Lectin | pt_BR |
| Subject | Skin | pt_BR |
| Subject | Cutaneous wound | pt_BR |
| Subject | Immunocompromised mice | pt_BR |
| DeCS | Camundongos | pt_BR |
| DeCS | Ricina | pt_BR |
