| Author | Oliveira, Fabiano | |
| Author | Rowton, Edgar | |
| Author | Aslan, Hamide | |
| Author | Gomes, Regis Bernardo Brandim | |
| Author | Castrovinci, Philip A | |
| Author | Alvarenga, Patricia Hessab | |
| Author | Abdeladhim, Maha | |
| Author | Teixeira, Clarissa | |
| Author | Meneses, Claudio | |
| Author | Kleeman, Lindsey T | |
| Author | Costa, Anderson Guimarães Baptista | |
| Author | Rowland, Tobin E | |
| Author | Gilmore, Dana C | |
| Author | Doumbia, Seydou | |
| Author | Reed, Steven G | |
| Author | Lawyer, Philip G | |
| Author | Andersen, John F | |
| Author | Kamhawi, Shaden | |
| Author | Valenzuela, Jesus G | |
| Access date | 2015-07-09T18:35:46Z | |
| Available date | 2015-07-09T18:35:46Z | |
| Document date | 2015 | |
| Citation | OLIVEIRA, F. et al. A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in non human primates. Science Translational Medicine, v. 7, n. 290, p. 290ra90, 2015. | pt_BR |
| ISSN | 1946-6242 | |
| URI | https://www.arca.fiocruz.br/handle/icict/11200 | |
| Language | eng | pt_BR |
| Publisher | American Association for the Advancement of Science | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Leishmaniose | pt_BR |
| Subject in Portuguese | Vacinas | pt_BR |
| Subject in Portuguese | Imunidade celular | pt_BR |
| Subject in Portuguese | Proteinas salivares | pt_BR |
| Subject in Portuguese | Saliva | pt_BR |
| Subject in Portuguese | Flebótomos | pt_BR |
| Subject in Portuguese | Animal | pt_BR |
| Subject in Portuguese | Leishmaniose Cutânea | pt_BR |
| Subject in Portuguese | Leishmaniose humana | pt_BR |
| Subject in Portuguese | Macacos rhesus | pt_BR |
| Title | A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in non human primates. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1126/scitranslmed.aaa3043 | |
| Abstract | Currently, there are no commercially available human vaccines against leishmaniasis. In rodents, cellular immunity to salivary proteins of sand fly vectors is associated to protection against leishmaniasis, making them worthy targets for further exploration as vaccines. We demonstrate that nonhuman primates (NHP) exposed to Phlebotomus duboscqi uninfected sand fly bites or immunized with salivary protein PdSP15 are protected against cutaneous leishmaniasis initiated by infected bites. Uninfected sand fly-exposed and 7 of 10 PdSP15-immunized rhesus macaques displayed a significant reduction in disease and parasite burden compared to controls. Protection correlated to the early appearance of Leishmania-specific CD4(+)IFN-γ(+) lymphocytes, suggesting that immunity to saliva or PdSP15 augments the host immune response to the parasites while maintaining minimal pathology. Notably, the 30% unprotected PdSP15-immunized NHP developed neither immunity to PdSP15 nor an accelerated Leishmania-specific immunity. Sera and peripheral blood mononuclear cells from individuals naturally exposed to P. duboscqi bites recognized PdSP15, demonstrating its immunogenicity in humans. PdSP15 sequence and structure show no homology to mammalian proteins, further demonstrating its potential as a component of a vaccine for human leishmaniasis. | pt_BR |
| Affilliation | National Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA | pt_BR |
| Affilliation | Walter Read Army Institute of Research. Department of Entomology. Silver Spring, MD, USA | pt_BR |
| Affilliation | National Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA | pt_BR |
| Affilliation | National Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | National Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Bioquimica Medica. Laboratório de Bioquímica e Resposta ao Estresse. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | National Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA | pt_BR |
| Affilliation | National Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | National Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA | pt_BR |
| Affilliation | National Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA | pt_BR |
| Affilliation | National Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA | pt_BR |
| Affilliation | Walter Read Army Institute of Research. Department of Entomology. Silver Spring, MD, USA | pt_BR |
| Affilliation | National Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA | pt_BR |
| Affilliation | University of Bamaco. Faculty of Medicine, Pharmacy and Odontostomatology. Bamako, Mali | pt_BR |
| Affilliation | Infection Disease Research Institute. Seattle, WA, USA | pt_BR |
| Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Diyarbakir, Turkey | pt_BR |
| Affilliation | Walter Read Army Institute of Research. Department of Entomology. Silver Spring, MD, USA | pt_BR |
| Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Diyarbakir, Turkey | pt_BR |
| Affilliation | National Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA | pt_BR |
| Affilliation | National Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
