| Author | Villalba, Julian A. | |
| Author | Bello, Gonzalo | |
| Author | Maes, Mailis | |
| Author | Sulbaran, Yoneira F. | |
| Author | Garzaro, Domingo | |
| Author | Loureiro, Carmen L. | |
| Author | Rangel, Hector R. | |
| Author | Waard, Jacobus H. de | |
| Author | Pujol, Flor H. | |
| Access date | 2015-07-13T12:46:48Z | |
| Available date | 2015-07-13T12:46:48Z | |
| Document date | 2013 | |
| Citation | VILLALBA, Julian A.; et al. HIV-1 epidemic in Warao Amerindians from Venezuela: spatial phylodynamics and epidemiological patterns. AIDS. v.27, n.11, p.1783-91, jul. 2013. | pt_BR |
| ISSN | 0269-9370 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11221 | |
| Language | por | pt_BR |
| Publisher | Lippincott Williams & Wilkins | pt_BR |
| Rights | restricted access | |
| Title | HIV-1 epidemic in Warao Amerindians from Venezuela: spatial phylodynamics and epidemiological patterns | pt_BR |
| Type | Article | |
| DOI | 10.1097/QAD.0b013e3283601bdb | pt_BR |
| Abstract | Objectives: We previously reported HIV-1 infection in Warao Amerindians from
Venezuela. The aim of this study was to evaluate the extent and the dynamic of
HIV-1 dissemination in eight Warao communities.
Design and Setting: HIV-1 infection was evaluated in 576 Warao Amerindians from
the Orinoco Delta. Partial HIV-1 pol sequences were analyzed to reconstruct the
spatiotemporal and demographic dynamics of the epidemic.
Results: HIV-1 antibodies were present in 9.55% of Warao Amerindians, ranging from
0 to 22%. A significantly higher prevalence was found in men (15.6%) compared with
women (2.6%), reaching up to 35% in men from one community. All but one isolates
were classified as subtype B. Warao’s HIV-1 subtype-B epidemic resulted from a single
viral introduction at around the early 2000s. After an initial phase of slow growth, the
subtype B started to spread at a fast rate (0.8/year) following two major routes of
migration within the communities.
Conclusion: A dramatic high prevalence was documented in almost all the communities
of Warao Amerindians from the Orinoco Delta tested for HIV-1 infection. This
epidemic resulted from the dissemination of a single HIV-1 subtype B founder strain
introduced about 10 years ago and its size is probably doubling every year, creating a
situation that can be devastating for this vulnerable Amerindian group. | pt_BR |
| Affilliation | Dirección Regional de Salud Estado Delta Amacuro. Tucupita, Venezuela / Lovelace Respiratory Research Institute. Albuquerque, New Mexico, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Instituto Venezolano de Investigaciones Científicas. Instituto de Biomedicina. Laboratório de Tuberculosis. Caracas, Venezuela. | pt_BR |
| Affilliation | Instituto Venezolano de Investigaciones Científicas. Laboratório de Virologia Molecular. Caracas. Venezuela. | pt_BR |
| Affilliation | Instituto Venezolano de Investigaciones Científicas. Laboratório de Virologia Molecular. Caracas. Venezuela. | pt_BR |
| Affilliation | Instituto Venezolano de Investigaciones Científicas. Laboratório de Virologia Molecular. Caracas. Venezuela. | pt_BR |
| Affilliation | Instituto Venezolano de Investigaciones Científicas. Laboratório de Virologia Molecular. Caracas. Venezuela. | pt_BR |
| Affilliation | Instituto Venezolano de Investigaciones Científicas. Instituto de Biomedicina. Laboratório de Tuberculosis. Caracas, Venezuela. | pt_BR |
| Affilliation | Instituto Venezolano de Investigaciones Científicas. Laboratório de Virologia Molecular. Caracas. Venezuela. | pt_BR |
| Subject | Amerinidians | pt_BR |
| Subject | Epidemiology | pt_BR |
| Subject | HIV-1 | pt_BR |
| Subject | Phylogeography | pt_BR |
| DeCS | HIV 1 | pt_BR |
| DeCS | Epidemiologia | pt_BR |
| DeCS | Filogeografia | pt_BR |
