| Author | Marrazzo, Jeanne M. | |
| Author | Rio, Carlos del | |
| Author | Holtgrave, David R. | |
| Author | Cohen, Myron S. | |
| Author | Kalichman, Seth C. | |
| Author | Mayer, Kenneth H. | |
| Author | Montaner, Julio S. G. | |
| Author | Wheeler, Darrell P. | |
| Author | Grant, Robert M. | |
| Author | Grinsztejn, Beatriz | |
| Author | Kumarasamy, N. | |
| Author | Shoptaw, Steven | |
| Author | Walensky, Rochelle P. | |
| Author | Dabis, Francois | |
| Author | Sugarman, Jeremy | |
| Author | Benson, Constance A. | |
| Access date | 2015-07-15T13:39:53Z | |
| Available date | 2015-07-15T13:39:53Z | |
| Document date | 2014 | |
| Citation | MARRAZZO, Jeanne M. et al. HIV prevention in clinical care settings: 2014 recommendations of the international antiviral society-USA panel. Journal of the American Medical Association, v. 312, n. 4, p. 390-409, Jul. 2014. | pt_BR |
| ISSN | 0098-7484 | |
| URI | https://www.arca.fiocruz.br/handle/icict/11365 | |
| Sponsorship | This work is supported and funded by the International Antiviral (formerly AIDS) Society–USA (IAS-USA), a mission-based, nonmembership, 501(c)(3) not-for-profit organization. The IAS−USA appointed members to the IAS−USA HIV Prevention Recommendations Panel to develop the recommendations and provided staff support. In the last 5 years, IAS−USA has received commercial support (grants) for selected continuing medical education (CME) activities that are pooled (ie, no single company supports any single effort) from Abbott Laboratories, AbbVie, Boehringer Ingelheim Pharmaceuticals, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Janssen Therapeutics, Merck & Co, Mylan, Pfizer, Salix Pharmaceuticals, Tibotec Therapeutics, Vertex Pharmaceuticals, and ViiV Healthcare. The designation of selected CME activities refers to the IAS−USA structure of accepting commercial support only if there are enough companies with competing products to meet the criteria for independence and only on programs appropriate for support by commercial sources (eg, recommendations are not supported by industry grants). No private sector funding was used to
support the effort. Panel members are not compensated for participation in the effort. | |
| Language | eng | pt_BR |
| Publisher | American Medical Association | pt_BR |
| Rights | open access | |
| Title | HIV prevention in clinical care settings: 2014 recommendations of the international antiviral society-USA panel | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1001/jama.2014.7999 | |
| Abstract | Importance: Emerging data warrant the integration of biomedical and behavioral recommendations for human immunodeficiency virus (HIV) prevention in clinical care settings. Objective: To provide current recommendations for the prevention of HIV infection in adults and adolescents for integration in clinical care settings. Data sources, study selection, and data synthesis: Data published or presented as abstracts at scientific conferences (past 17 years) were systematically searched and reviewed by the International Antiviral (formerly AIDS) Society-USA HIV Prevention Recommendations Panel. Panel members supplied additional relevant publications, reviewed available data, and formed recommendations by full-panel consensus. Results: Testing for HIV is recommended at least once for all adults and adolescents, with repeated testing for those at increased risk of acquiring HIV. Clinicians should be alert to the possibility of acute HIV infection and promptly pursue diagnostic testing if suspected. At diagnosis of HIV, all individuals should be linked to care for timely initiation of antiretroviral therapy (ART). Support for adherence and retention in care, individualized risk assessment and counseling, assistance with partner notification, and periodic screening for common sexually transmitted infections (STIs) is recommended for HIV-infected individuals as part of care. In HIV-uninfected patients, those persons at high risk of HIV infection should be prioritized for delivery of interventions such as preexposure prophylaxis and individualized counseling on risk reduction. Daily emtricitabine/tenofovir disoproxil fumarate is recommended as preexposure prophylaxis for persons at high risk for HIV based on background incidence or recent diagnosis of incident STIs, use of injection drugs or shared needles, or recent use of nonoccupational postexposure prophylaxis; ongoing use of preexposure prophylaxis should be guided by regular risk assessment. For persons who inject drugs, harm reduction services should be provided (needle and syringe exchange programs, supervised injection, and available medically assisted therapies, including opioid agonists and antagonists); low-threshold detoxification and drug cessation programs should be made available. Postexposure prophylaxis is recommended for all persons who have sustained a mucosal or parenteral exposure to HIV from a known infected source and should be initiated as soon as possible. Conclusions and relevance: Data support the integration of biomedical and behavioral approaches for prevention of HIV infection in clinical care settings. A concerted effort to implement combination strategies for HIV prevention is needed to realize the goal of an AIDS-free generation. | pt_BR |
| Affilliation | University of Washington. Seattle, WA, USA. | pt_BR |
| Affilliation | Emory University. Atlanta, GA, USA. | pt_BR |
| Affilliation | The Johns Hopkins Bloomberg School of Public Health. Baltimore, MD, USA. | pt_BR |
| Affilliation | University of North Carolina at Chapel Hill. Chapel Hill, NC, USA. | pt_BR |
| Affilliation | University of Connecticut. Storrs, CT, USA. | pt_BR |
| Affilliation | Harvard Medical School. Boston, MA, USA. | pt_BR |
| Affilliation | University of British Columbia. Vancouver, BC, Canada. | pt_BR |
| Affilliation | Loyola University Chicago. Chicago, IL, USA. | pt_BR |
| Affilliation | University of California San Francisco. San Francisco, CA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | YR Gaitonde Centre for AIDS Research and Education. Chennai, India. | pt_BR |
| Affilliation | University of California Los Angeles. Los Angeles, CA, USA. | pt_BR |
| Affilliation | Massachusetts General Hospital. Boston, MA, USA. | pt_BR |
| Affilliation | Université de Bordeaux. Bordeaux, France. | pt_BR |
| Affilliation | The Johns Hopkins University. Baltimore, MD, USA. | pt_BR |
| Affilliation | University of California San Diego. San Diego, CA, USA. | pt_BR |
| Subject | HIV | pt_BR |
| Subject | Highly Active Antiretroviral Therapy | pt_BR |
| Subject | Statistical Analysis | pt_BR |
| Subject | HIV Infections | pt_BR |
| Subject | Prevention & control | |
| e-ISSN | 1538-3598 | |
