| Author | Kouri, Vivian | |
| Author | Cunha, Antonio Ricardo Khouri | |
| Author | Alemán, Yoan | |
| Author | Abrahantes, Yeissel | |
| Author | Vercauteren, Jurgen | |
| Author | Peña, Andrea Clemencia Pineda | |
| Author | Theys, Kristof | |
| Author | Megens, Sarah | |
| Author | Moutschene, Michel | |
| Author | Pfeifer, Nico | |
| Author | Van Weyenbergh, Johan Jozef Rosa Maria | |
| Author | Pérez, Ana B | |
| Author | Pérez, Jorge | |
| Author | Pérez, Lissette | |
| Author | Van Laethem, Kristel | |
| Author | Vandamme, Anne-Mieke | |
| Access date | 2015-07-15T18:04:15Z | |
| Available date | 2015-07-15T18:04:15Z | |
| Document date | 2015 | |
| Citation | KOURI, V. et al. CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With apid Progression to AIDS in Cuba. EBioMedicine, v. 2, n. 3, p. 244-254, 2015. | pt_BR |
| ISSN | 2352-3964 | |
| URI | https://www.arca.fiocruz.br/handle/icict/11383 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Title | CRF19_cpx is an Evolutionary fit HIV-1 Variant Strongly Associated With Rapid Progression to AIDS in Cuba. | pt_BR |
| Type | Article | pt_BR |
| DOI | dx.doi.org/10.1016/j.ebiom.2015.01.015 | |
| Abstract | Background: Clinicians reported an increasing trend of rapid progression (RP) (AIDS within 3 years of infection)
in Cuba.
Methods: Recently infected patientswere prospectively sampled, 52 RP at AIDS diagnosis (AIDS-RP) and 21without
AIDS in the same time frame (non-AIDS). 22 patients were sampled at AIDS diagnosis (chronic-AIDS) retrospectively
assessed as N3 years infected. Clinical, demographic, virological, epidemiological and immunological
data were collected. Pol and env sequenceswere used for subtyping, transmission cluster analysis, and prediction
of resistance, co-receptor use and evolutionary fitness. Host, immunological and viral predictors of RP were explored
through data mining.
Findings: Subtyping revealed 26 subtype B strains, 6 C, 6 CRF18_cpx, 9 CRF19_cpx, 29 BG-recombinants and other subtypes/
URFs. All patients infected with CRF19 belonged to the AIDS-RP group. Data mining identified CRF19, oral candidiasis
and RANTES levels as the strongest predictors of AIDS-RP. CRF19 was more frequently predicted to use the
CXCR4 co-receptor, had higher fitness scores in the protease region, and patients had higher viral load at diagnosis.
Interpretation: CRF19 is a recombinant of subtype D (C-part of Gag, PR, RT and nef), subtype A (N-part of Gag,
Integrase, Env) and subtype G (Vif, Vpr, Vpu and C-part of Env). Since subtypes D and A have been associated with
respectively faster and slower disease progression, our findings might indicate a fit PR driving high viral load,
which in combination with co-infections may boost RANTES levels and thus CXCR4 use, potentially explaining the
fast progression. We propose that CRF19 is evolutionary very fit and causing rapid progression to AIDS in many
newly infected patients in Cuba. | pt_BR |
| Affilliation | Institute of Tropical Medicine Pedro Kourí. Virology Department. Autopista Novia del Mediodía. Havana City, Cuba | pt_BR |
| Affilliation | KU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Laboratório de Imunoparasitologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Institute of Tropical Medicine Pedro Kourí. Virology Department. Autopista Novia del Mediodía. Havana City, Cuba | pt_BR |
| Affilliation | Institute of Tropical Medicine Pedro Kourí. Virology Department. Autopista Novia del Mediodía. Havana City, Cuba | pt_BR |
| Affilliation | KU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium | pt_BR |
| Affilliation | KU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium / Universidad del Rosario. Faculty of Sciences and Mathematics. Clinical and Molecular Infectious Diseases Group. Bogotá, Colombia | pt_BR |
| Affilliation | KU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium | pt_BR |
| Affilliation | KU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium | pt_BR |
| Affilliation | Centre Hospitalier Universitaire de Liège. AIDS Reference Center. Liège, Belgium | pt_BR |
| Affilliation | Max Planck Institute for Informatics. Department of Computational Biology and Applied Algorithmics. Saarbrücken, Germany | pt_BR |
| Affilliation | KU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium | pt_BR |
| Affilliation | Institute of Tropical Medicine Pedro Kourí. Virology Department. Autopista Novia del Mediodía. Havana City, Cuba | pt_BR |
| Affilliation | Institute of Tropical Medicine Pedro Kourí. Virology Department. Autopista Novia del Mediodía. Havana City, Cuba | pt_BR |
| Affilliation | Institute of Tropical Medicine Pedro Kourí. Virology Department. Autopista Novia del Mediodía. Havana City, Cuba | pt_BR |
| Affilliation | KU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium | pt_BR |
| Affilliation | KU Leuven. Rega Institute for Medical Research. Department of Microbiology and Immunology. Laboratory of Clinical and Epidemiological Virology. Leuven, Belgium / Universidade Nova de Lisboa. Instituto de Higiene e Medicina Tropical. Centro de Malária e outras Doenças Tropicais and Unidade de Microbiologia. Lisbon, Portugal | pt_BR |
| Subject | CRF19 | pt_BR |
| Subject | HIV-1 | pt_BR |
| Subject | Variant | pt_BR |
| Subject | Progression to AIDS | pt_BR |
| Subject | Cuba | pt_BR |
