| Author | Martins, Ronaldo Soares | |
| Author | Martins Filho, Olindo Assis | |
| Author | Gonçales, Neiva Sellan Lopes | |
| Author | Del Castillo, Dora Méndez | |
| Author | Silva, Luciana Diniz | |
| Author | Faria, Luciana Costa | |
| Author | Teixeira, Rosângela | |
| Access date | 2015-08-06T17:32:59Z | |
| Available date | 2015-08-06T17:32:59Z | |
| Document date | 2012 | |
| Citation | MARTINS, Ronaldo Soares et al. Kinetics of hepatitis C virus load and hemodialysis: is there any influence of the reuse of dialysis membrane on HCV viremia? Scandinavian Journal of Infectious Diseases,vol.44, n. 3, p. 190-196, 2012. | pt_BR |
| ISSN | 0036-5548 | |
| URI | https://www.arca.fiocruz.br/handle/icict/11428 | |
| Language | eng | pt_BR |
| Publisher | Society for the Publication of Acta medica Scandinavica | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Kinetics of hepatitis C virus load and hemodialysis: is there any influence of the reuse of dialysis membrane on HCV viremia? | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.3109/00365548.2011.627377 | |
| Abstract | Background: Patients with chronic kidney disease (CKD) on regular hemodialysis are at increased risk of acquiring hepatitis C virus (HCV). Although controversial, a distinct dynamic of the HCV load has been reported in this group – a lower HCV viremia compared to non-uremic patients. The reasons for this remain unclear, but the host immune response related to the hemodialysis procedure and the reuse of dialysis membranes are the most investigated factors.
Methods: We analyzed the kinetics of HCV RNA viremia in 21 hemodialysis patients infected with genotype 1, through a highly sensitive quantitative method (real-time polymerase chain reaction), immediately before and at the end of the first use and the last reuse of the cellulose diacetate dialysis membrane. Results: Initial HCV load did not correlate with demographic or biochemical parameters, but higher HCV viremia was associated with a longer time on hemodialysis (r = 0.44, p = 0.04). Although not significant, HCV RNA decreased in 11/21 (52.3%) patients after the first dialysis session (median 279,000 vs 176,000 IU/ml, p = 0.91). However, a significant increase in HCV RNA viremia was observed in 17/21 (80.9%) patients after the tenth session (median 187,000 vs 342,000 IU/ml, p = 0.009).
Conclusions: Except for the first session of hemodialysis, we did not confirm a decrease in HCV viremia related to the time on hemodialysis or with the reuse of the dialysis membrane. Factors other than the reuse of the dialysis membrane might be involved in the multifaceted | pt_BR |
| Affilliation | Hospital Felício Rocho. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratório de Biomarcadores. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade de Campinas. Laboratório de Biologia Molecular. Campinas, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Hospital das Clínicas. Núcleo de Ações e Pesquisa em Apoio Diagnóstico. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Hospital das Clínicas. Ambulatório de Hepatites Virais do Instituto Alfa de Gastroenterologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Hospital das Clínicas. Ambulatório de Hepatites Virais do Instituto Alfa de Gastroenterologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Hospital das Clínicas. Ambulatório de Hepatites Virais do Instituto Alfa de Gastroenterologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Dialysis membrane | pt_BR |
| Subject | reuse | pt_BR |
| Subject | HCV viremia | pt_BR |
| Subject | hemodialysis | pt_BR |
| xmlui.metadata.dc.subject.ods | 12 Consumo e produção responsáveis | |
