| Author | Arcanjo, Angélica F. | |
| Author | Freitas, Isabel F. LaRocque de | |
| Author | Rocha, Juliana Dutra B. | |
| Author | Zamith, Daniel | |
| Author | Silva, Ana Caroline Costa da | |
| Author | Nunes, Marise Pinheiro | |
| Author | Santos, Fábio P. Mesquita | |
| Author | Morrot, Alexandre | |
| Author | Filardy, Alessandra A. | |
| Author | Mariano, Mario | |
| Author | Melo, Christianne Bandeira | |
| Author | Reis, George A. dos | |
| Author | Ricardo, Debora Decote | |
| Author | Lima, Célio Geraldo Freire de | |
| Access date | 2015-08-19T13:49:19Z | |
| Available date | 2015-08-19T13:49:19Z | |
| Document date | 2015 | |
| Citation | ARCANJO, Angélica F.; et al. The PGE2/IL-10 Axis Determines Susceptibility of B-1 Cell-Derived Phagocytes (B-1CDP) to Leishmania major Infection. PLos One, v.10, n.5, 18p, may 2015. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11482 | |
| Language | eng | pt_BR |
| Publisher | Plos One | pt_BR |
| Rights | open access | |
| Title | The PGE2/IL-10 Axis Determines Susceptibility of B-1 Cell-Derived Phagocytes (B-1CDP) to Leishmania major Infection | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0124888 | pt_BR |
| Abstract | B-1 cells can be differentiated from B-2 cells because they are predominantly located in the
peritoneal and pleural cavities and have distinct phenotypic patterns and activation properties.
A mononuclear phagocyte derived from B-1 cells (B-1CDP) has been described. As
the B-1CDP cells migrate to inflammatory/infectious sites and exhibit phagocytic capacity,
the microbicidal ability of these cells was investigated using the Leishmania major infection
model in vitro. The data obtained in this study demonstrate that B-1CDP cells are more susceptible
to infection than peritoneal macrophages, since B-1CDP cells have a higher number
of intracellular amastigotes forms and consequently release a larger number of
promastigotes. Exacerbated infection by L. major required lipid bodies/PGE2 and IL-10 by
B-1CDP cells. Both infection and the production of IL-10 were decreased when PGE2 production
was blocked by NSAIDs. The involvement of IL-10 in this mechanism was confirmed,
since B-1CDP cells from IL-10 KO mice are more competent to control L. major
infection than cells from wild type mice. These findings further characterize the B-1CDP
cells as an important mononuclear phagocyte that plays a previously unrecognized role in
host responses to L. major infection, most likely via PGE2-driven production of IL-10. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal Rural do Rio de Janeiro. Departamento de Veterinária. Seropédica, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal de São Paulo. Departmento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Departamento de Veterinária. Seropédica, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Leishmania major | pt_BR |
| Subject | Phagocytes | pt_BR |
| Subject | B-1 Cell-Derived Phagocytes (B-1CDP) | pt_BR |
| Subject | B-1CDP cells | pt_BR |
| DeCS | Leishmania major | pt_BR |
| DeCS | Fagócitos | pt_BR |
