| Author | Hottz, Eugenio D. | |
| Author | Monteiro, Ana Paula T. | |
| Author | Bozza, Fernando A. | |
| Author | Bozza, Patrícia T. | |
| Access date | 2015-08-19T13:49:22Z | |
| Available date | 2015-08-19T13:49:22Z | |
| Document date | 2015 | |
| Citation | HOTTZ, Eugenio D.; et al. Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases?. Mediators of Inflammation, v.2015, Article ID 435783, 7p, 2015. | pt_BR |
| ISSN | 0962-9351 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11498 | |
| Language | eng | pt_BR |
| Publisher | Hindawi Publishing Corporation | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Doenças Inflamatórias | pt_BR |
| Title | Inflammasome in Platelets: Allying Coagulation and Inflammation in Infectious and Sterile Diseases? | pt_BR |
| Type | Article | |
| DOI | 10.1155/2015/435783 | pt_BR |
| Abstract | Platelets are crucial effector cells in hemostasis. In addition, platelets are increasingly recognized as major inflammatory cells
with key roles in innate and adaptive immune responses. Activated platelets have key thromboinflammatory activities linking
coagulation to inflammatory response in a variety of coagulation disorders and vasculopathies. Recently identified inflammatory
activities of platelets include the synthesis of IL-1𝛽 from spliced pre-RNA, as well as the presence and assembly of inflammasome
which intermediate IL-1𝛽 secretion. Here we review the mechanisms by which platelets activate translation machinery and
inflammasome assembly to synthesize and release IL-1𝛽. The contributions of these processes to protective and pathogenic
responses during infectious and inflammatory diseases are discussed. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Medicina Intensiva. Rio de Janeiro, RJ, Brasil / Instituto D`Or de Pesquisa e Ensino. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Inflamation | pt_BR |
| Subject | Platelets | pt_BR |
| Subject | Hemotasis | pt_BR |
| DeCS | Plaquetas | pt_BR |
| DeCS | Inflamação | pt_BR |
| DeCS | Hemostasia | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
