| Author | Araki, Alejandra S. | |
| Author | Ferreira, Gabriel E. M. | |
| Author | Mazzoni, Camila J. | |
| Author | Souza, Nataly A. | |
| Author | Machado, Ricardo C. | |
| Author | Bruno, Rafaela V. | |
| Author | Peixoto, Alexandre Afrânio | |
| Access date | 2015-08-19T13:49:33Z | |
| Available date | 2015-08-19T13:49:33Z | |
| Document date | 2013 | pt_BR |
| Citation | ARAKI, Alejandra S.; et al. Multilocus Analysis of Divergence and Introgression in Sympatric and Allopatric Sibling Species of the Lutzomyia longipalpis Complex in Brazil. PLoS Negl Trop Dis, v.7, n.10, 13p, 2013. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11561 | |
| Language | eng | pt_BR |
| Publisher | Plos One | pt_BR |
| Rights | open access | pt_BR |
| Title | Multilocus Analysis of Divergence and Introgression in Sympatric and Allopatric Sibling Species of the Lutzomyia longipalpis Complex in Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pntd.0002495 | pt_BR |
| Abstract | Background: Lutzomyia longipalpis, the main vector of visceral leishmaniasis in Latin America, is a complex of sibling
species. In Brazil, a number of very closely related sibling species have been revealed by the analyses of copulation songs,
sex pheromones and molecular markers. However, the level of divergence and gene flow between the sibling species
remains unclear. Brazilian populations of this vector can be divided in two main groups: one producing Burst-type songs
and the Cembrene-1 pheromone and a second more diverse group producing various Pulse song subtypes and different
pheromones.
Methodology/Principal Findings: We analyzed 21 nuclear loci in two pairs of Brazilian populations: two sympatric
populations from the Sobral locality (1S and 2S) in northeastern Brazil and two allopatric populations from the Lapinha and
Pancas localities in southeastern Brazil. Pancas and Sobral 2S are populations of the Burst/Cembrene-1 species while
Lapinha and Sobral 1S are two putative incipient species producing the same pheromone and similar Pulse song subtypes.
The multilocus analysis strongly suggests the occurrence of gene flow during the divergence between the sibling species,
with different levels of introgression between loci. Moreover, this differential introgression is asymmetrical, with estimated
gene flow being higher in the direction of the Burst/Cembrene-1 species.
Conclusions/Significance: The results indicate that introgressive hybridization has been a crucial phenomenon in shaping
the genome of the L. longipalpis complex. This has possible epidemiological implications and is particularly interesting
considering the potential for increased introgression caused by man-made environmental changes and the current trend of
leishmaniasis urbanization in Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Laborato´ rio de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil / | pt_BR |
| Affilliation | Institut für Zoo-und Wildtierforschung. Berlin, Germany / Berlin Center for Genomics in Biodiversity Research. Berlin, Germany. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laborato´ rio de Transmissores de Leishmanioses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Cieˆncia e Tecnologia em Entomologia Molecular (INCT-EM); Rio de Janeiro, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Cieˆncia e Tecnologia em Entomologia Molecular (INCT-EM). Rio de Janeiro, Brasil. | pt_BR |
| Subject | Lutzomyia longipalpis | pt_BR |
| Subject | Visceral leishmaniasis | pt_BR |
| Subject | Allopatric Sibling Species | pt_BR |
| DeCS | Leishmaniose Visceral | pt_BR |
