| Author | Neves, Parícia C. C. | |
| Author | Santos, Juliana R. | |
| Author | Tubarão, Luciana N. | |
| Author | Bonaldo, Myrna C. | |
| Author | Galler, Ricardo | |
| Access date | 2015-08-19T13:49:34Z | |
| Available date | 2015-08-19T13:49:34Z | |
| Document date | 2013 | |
| Citation | NEVES, Patrícia C. C.; et al. Early IFN-Gamma Production after YF 17D Vaccine Virus Immunization in Mice and Its Association with Adaptive Immune Responses. Plos One, v.8, n.12, 16p, dec. 2013. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11572 | |
| Language | eng | pt_BR |
| Publisher | Plos One | pt_BR |
| Rights | open access | |
| Title | Early IFN-Gamma Production after YF 17D Vaccine Virus Immunization in Mice and Its Association with Adaptive Immune Responses | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pone.0081953 | pt_BR |
| Abstract | Yellow Fever vaccine is one of the most efficacious human vaccines ever made. The vaccine (YF 17D) virus induces
polyvalent immune responses, with a mixed TH1/TH2 CD4+ cell profile, which results in robust T CD8+ responses and
high titers of neutralizing antibody. In recent years, it has been suggested that early events after yellow fever
vaccination are crucial to the development of adequate acquired immunity. We have previously shown that primary
immunization of humans and monkeys with YF 17D virus vaccine resulted in the early synthesis of IFN-γ. Herein we
have demonstrated, for the first time that early IFN-γ production after yellow fever vaccination is a feature also of
murine infection and is much more pronounced in the C57BL/6 strain compared to the BALB/c strain. Likewise, in
C57BL/6 strain, we have observed the highest CD8+ T cells responses as well as higher titers of neutralizing
antibodies and total anti-YF IgG. Regardless of this intense IFN-γ response in mice, it was not possible to see higher
titers of IgG2a in relation to IgG1 in both mice lineages. However, IgG2a titers were positively correlated to
neutralizing antibodies levels, pointing to an important role of IFN-γ in eliciting high quality responses against YF
17D, therefore influencing the immunogenicity of this vaccine. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Vice-diretoria de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Vice-diretoria de Desenvolvimento Tecnológico. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | YF 17D Vaccine Virus Immunization | pt_BR |
| Subject | Early IFN-Gamma Production | pt_BR |
| Subject | Immune Responses | pt_BR |
| Subject | Yellow Fever | pt_BR |
| DeCS | Febre Amarela | pt_BR |
| DeCS | Vacinas | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
