| Author | Costa, Elis Regina Dalla | |
| Author | Lazzarini, Luiz Claudio Oliveira | |
| Author | Perizzolo, Paulo Fernando | |
| Author | Diaz, Chyntia Acosta | |
| Author | Spies, Fernanda S. | |
| Author | Costa, Lucas Laux | |
| Author | Ribeiro, Andrezza W. | |
| Author | Barroco, Caroline | |
| Author | Schuh, Sandra Jungblut | |
| Author | Pereira, Maria Aparecida da Silva | |
| Author | Dias, Claudia F. | |
| Author | Gomes, Harrison M. | |
| Author | Unis, Gisela | |
| Author | Zaha, Arnaldo | |
| Author | Silva, Pedro E. Almeida da | |
| Author | Suffys, Phillip | |
| Author | Rossetti, Maria L. R. | |
| Access date | 2015-08-19T13:49:35Z | |
| Available date | 2015-08-19T13:49:35Z | |
| Document date | 2013 | |
| Citation | COSTA, Elis Regina Dalla; Mycobacterium tuberculosis of the RDRio Genotype Is the Predominant Cause of Tuberculosis and Associated with Multidrug Resistance in Porto Alegre City, South Brazil. Journal of Clinical Microbiology, v.51, n.4, p. 1071–1077, April 2013. | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11577 | |
| Language | eng | pt_BR |
| Publisher | American Society for Microbiology | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Porto Alegre | pt_BR |
| Title | Mycobacterium tuberculosis of the RDRio Genotype Is the Predominant Cause of Tuberculosis and Associated with Multidrug Resistance in Porto Alegre City, South Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1128/JCM.01511-12 | pt_BR |
| Abstract | Spoligotyping has shown Mycobacterium tuberculosis strains to be composed of different lineages, and some of them are not just
geographically restricted but also affect specific ethnic populations and are associated with outbreaks and drug resistance. We
recently described a particular subtype within the Latin American-Mediterranean (LAM) family, called RDRio, widespread in
Brazil. Moreover, recent data also indicate that RDRio is present in many countries on all continents and is associated with cavitary
disease and multidrug resistance (MDR). To further explore the relationship between RDRio and MDR, we conducted a
study in a tuberculosis (TB) reference center responsible for the care of MDR patients in Rio Grande do Sul, the southernmost
Brazilian state. From a collection of 237 clinical isolates, RDRio alone was responsible for one-half of all MDR cases, including
one large group composed of strains with identical IS6110-restriction fragment length polymorphism (RFLP) and having the
LAM5 signature. We additionally had complete data records for 96 patients and could make comparisons between the presence
and absence of RDRio. No difference in clinical, radiological or laboratory features was observed, but a significantly greater number
of cases with MDR were described in patients infected with an RDRio strain (P 0.0015). Altogether, RDRio was responsible
for 38% of all TB cases. These data support and confirmed previous findings that RDRio is the main agent responsible for TB in
Brazil and is associated with drug resistance. Considering that RDRio is a globally distributed genotype, such findings raise concern
about the increase in MDR in certain human populations. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde (FEPPS). Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Unidade de Pesquisa em Tuberculose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde (FEPPS). Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde (FEPPS). Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde (FEPPS). Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde (FEPPS). Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde (FEPPS). Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Hospital Sanatório Partenon (HSP), Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Sanatório Partenon (HSP), Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Sanatório Partenon (HSP), Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Universidade de Rio Grande. Rio Grande, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Estadual de Produção e Pesquisa em Saúde (FEPPS). Porto Alegre, RS, Brasil / Universidade Luterana do Brazil (ULBRA/RS). Porto Alegre, RS, Brasil. | pt_BR |
| Subject | Mycobacterium tuberculosis | pt_BR |
| Subject | RDRio Genotype | pt_BR |
| Subject | Multidrug Resistance | pt_BR |
| Subject | Porto Alegre | pt_BR |
| DeCS | Mycobacterium tuberculosis | pt_BR |
| DeCS | Tuberculose | pt_BR |
| DeCS | Genótipos | pt_BR |
| DeCS | Resistência a Múltiplos Medicamentos | pt_BR |
