Author | Sharma, Shruti | |
Author | Oliveira, Rosane Batista de | |
Author | Kalantari, Parisa | |
Author | Parroche, Peggy | |
Author | Goutagny, Nadege | |
Author | Jiang, Zhaozhao | |
Author | Chan, Jennie | |
Author | Bartholomeu, Daniella Castanheira | |
Author | Lauw, Fanny | |
Author | Hall, J. Perry | |
Author | Barber, Glen N. | |
Author | Gazzinelli, Ricardo Tostes | |
Author | Fitzgerald, Katherine A. | |
Author | Golenbock, Douglas Taylor | |
Access date | 2015-08-31T18:10:09Z | |
Available date | 2015-08-31T18:10:09Z | |
Document date | 2011 | |
Citation | SHARMA, Shruti et al. Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome. Immunity, vol. 35, n. 2, p.194-207, 2011. | pt_BR |
ISSN | 1074-7613 Immunity | |
URI | https://www.arca.fiocruz.br/handle/icict/11663 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome | pt_BR |
Type | Article | pt_BR |
Abstract | Although Toll-like receptor 9 (TLR9) has been implicated in regulating cytokine and type I interferon (IFN) production during malaria in humans and mice, the high AT content of the Plasmodium falciparum genome prompted us to examine the possibility that malarial DNA triggered TLR9-independent DNA sensing pathways. Over 6000 ATTTTTAC (“AT-rich”) motifs are present in the genome of P. falciparum, which we show here potently induce type I IFNs. Parasite DNA, parasitized erythrocytes and oligonucleotides containing the AT-r motif induce type I IFNs via a pathway that did not involve previously described sensors including TLR9, DAI, RNA polymerase-III or IFI16/p204. Rather, AT-rich DNA sensing involved an unknown receptor that coupled to STING, TBK1 and IRF3-IRF7 signaling pathway. Mice lacking both IRF3 and IRF7, the kinase TBK1 or the type I IFN receptor were resistant to otherwise lethal cerebral malaria. Collectively, these observations implicate AT-rich DNA sensing via STING, TBK1 and IRF3-IRF7 in P. falciparum malaria. | pt_BR |
Affilliation | University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USA | pt_BR |
Affilliation | University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USA | pt_BR |
Affilliation | University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USA | pt_BR |
Affilliation | University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USA | pt_BR |
Affilliation | University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USA | pt_BR |
Affilliation | University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USA | pt_BR |
Affilliation | University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USA | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia, Bioquimica e Imunologia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USA | pt_BR |
Affilliation | Department of Inflammation and Remodeling, Pfizer. Cambridge, MA, USA | pt_BR |
Affilliation | University of Miami School of Medicine. Department of Medicine. Division of Hematology and Oncology. Miami, FL, USA | pt_BR |
Affilliation | University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USA/Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Parasitologia, Bioquimica e Imunologia. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratorio de Imunopatologia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USA | pt_BR |
Affilliation | University of Massachusetts Medical School. Department of Medicine. Division of Infectious Diseases and Immunology. Worcester, MA, USA | pt_BR |
Subject | Malaria | pt_BR |
Subject | Plasmodium falciparum | pt_BR |